DegronMD

Uniprot ID: Q9NP74

Source protein: Palmdelphin

Source gene: PALMD

Class: DEG_SCF_FBW7_2

Location: 347:353

E3 ligase: FBXW7

DEGRON score: 0.9882

ASA_SCORE: 82.6

COIL: 0.6926

CONS_SCORE: 0.4448

DSS_SCORE: 0.6435

HELIX: 0.1916

FCONS_SCORE: 1.1174

RIG_SCORE: 0.7019

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P343L	TCGA-43-6770	LUSC	TCGA	LMTPWEE	DEG_SCF_FBW7_2	0.2222
p.P343L	TCGA-EE-A3J7	SKCM	TCGA	LMTPWEE	DEG_SCF_FBW7_2	0.2222
p.P343L	DO27644	LUSC	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.2222
p.P343L	DO48770	SKCM	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.2222
p.D361Y	TCGA-AP-A1E0	UCEC	TCGA	LMTPWEE	DEG_SCF_FBW7_2	0.1111
p.D361Y	DO43154	UCEC	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.1111
p.P350H	TCGA-DA-A1I7	SKCM	TCGA	LMTPWEE	DEG_SCF_FBW7_2	0.7694
p.P350H	DO37951	SKCM	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.7694
p.R346W	TCGA-G9-6377	PRAD	TCGA	LMTPWEE	DEG_SCF_FBW7_2	0.3056
p.R346W	DO36348	PRAD	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.3056
p.D361G	DO231690	LINC	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.1111
p.S354L	DO220889	MELA	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.3056
p.P350L	DO220886	MELA	ICGC	LMTPWEE	DEG_SCF_FBW7_2	0.7582
p.E352K	SIDM01060	Melanoma	GDSC	LMTPWEE	DEG_SCF_FBW7_2	0.591
p.E352K	ACH-000882	Skin Cancer	CCLE	LMTPWEE	DEG_SCF_FBW7_2	0.591
p.E352K	IGR-1	skin	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	0.591
p.K339E	SIDM00537	Colorectal Carcinoma	GDSC	LMTPWEE	DEG_SCF_FBW7_2	0.5556
p.K339E	ACH-000982	Colon/Colorectal Cancer	CCLE	LMTPWEE	DEG_SCF_FBW7_2	0.5556
p.K339E	ACH-001345	Colon/Colorectal Cancer	CCLE	LMTPWEE	DEG_SCF_FBW7_2	0.5556
p.K339E	GP5d	large_intestine	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	0.5556
p.G339A	CHP-126	autonomic_ganglia	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	0.5556
p.I359N	ARH-77	haematopoietic_and_lymphoid_tissue	COSMIC	LMTPWEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP74	Palmdelphin	DEG_SCF_FBW7_2	347:353	LMTPWEE	FBXW7	0.9882	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons