DegronMD

Uniprot ID: Q9NP74

Source protein: Palmdelphin

Source gene: PALMD

Class: DEG_APCC_DBOX_1

Location: 169:177

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5662

ASA_SCORE: 92.9556

COIL: 0.3897

CONS_SCORE: 0.7987

DSS_SCORE: 0.4212

HELIX: 0.4354

FCONS_SCORE: 1.2268

RIG_SCORE: 0.8099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D183Y	TCGA-B5-A0JY	UCEC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	0.1667
p.D183Y	DO43041	UCEC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	0.1667
p.E167K	TCGA-DX-A6BB	SARC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	0.2778
p.E167K	DO219996	SARC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	0.2778
p.A175V	TCGA-EL-A3MZ	THCA	TCGA	NRKALYAME	DEG_APCC_DBOX_1	0.5825
p.A175V	DO39505	THCA	ICGC	NRKALYAME	DEG_APCC_DBOX_1	0.5825
p.A175T	TCGA-EO-A22R	UCEC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	0.6028
p.A175T	DO42713	UCEC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	0.6028
p.E161K	TCGA-IR-A3LH	CESC	TCGA	NRKALYAME	DEG_APCC_DBOX_1	0.1111
p.E161K	DO44381	CESC	ICGC	NRKALYAME	DEG_APCC_DBOX_1	0.1111
p.G187E	DO222847	MELA	ICGC	NRKALYAME	DEG_APCC_DBOX_1	0.0556
p.V180F	SIDM00789	Colorectal Carcinoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	0.25
p.V180F	HCT-15	large_intestine	COSMIC	NRKALYAME	DEG_APCC_DBOX_1	0.25
p.N169H	SIDM00197	Ewing's Sarcoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	0.6312
p.N169H	SIDM01099	Neuroblastoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	0.6312
p.N169H	SIDM00256	Neuroblastoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	0.6312
p.E177K	SIDM00217	Colorectal Carcinoma	GDSC	NRKALYAME	DEG_APCC_DBOX_1	0.591
p.E177K	ACH-000999	Colon/Colorectal Cancer	CCLE	NRKALYAME	DEG_APCC_DBOX_1	0.591
p.E177K	SNU-1040	large_intestine	COSMIC	NRKALYAME	DEG_APCC_DBOX_1	0.591
p.T186I	RPMI-2650	upper_aerodigestive_tract	COSMIC	NRKALYAME	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NP74	Palmdelphin	DEG_APCC_DBOX_1	169:177	NRKALYAME	APC,CDC20,FZR1	0.5662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons