DegronMD

Uniprot ID: Q12846

Source protein: Syntaxin-4

Source gene: STX4

Class: DEG_SCF_FBW7_2

Location: 69:76

E3 ligase: FBXW7

DEGRON score: 0.981

ASA_SCORE: 80.575

COIL: 0.6998

CONS_SCORE: 0.3371

DSS_SCORE: 0.4012

HELIX: 0.2841

FCONS_SCORE: 0.8977

RIG_SCORE: 0.7783

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L74F	TCGA-D3-A8GB	SKCM	TCGA	ILATPLPE	DEG_SCF_FBW7_2	0.587
p.L74F	DO50280	SKCM	ICGC	ILATPLPE	DEG_SCF_FBW7_2	0.587
p.K80T	DO225089	BRCA	ICGC	ILATPLPE	DEG_SCF_FBW7_2	0.6667
p.I69F	DO1125	BRCA	ICGC	ILATPLPE	DEG_SCF_FBW7_2	0.7415
p.S78I	DO229022	LICA	ICGC	ILATPLPE	DEG_SCF_FBW7_2	0.7222
p.V59I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ILATPLPE	DEG_SCF_FBW7_2	0.0556
p.V59I	ACH-001127	Leukemia	CCLE	ILATPLPE	DEG_SCF_FBW7_2	0.0556
p.V59I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ILATPLPE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12846	Syntaxin-4	DEG_SCF_FBW7_2	69:76	ILATPLPE	FBXW7	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons