DegronMD - Q12846(STX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E113D	TCGA-BK-A6W3	UCEC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.1111
p.E113D	DO50076	UCEC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.1111
p.L74F	TCGA-D3-A8GB	SKCM	TCGA	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation altering degron motif	0.587
p.L74F	DO50280	SKCM	ICGC	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation altering degron motif	0.587
p.R98H	TCGA-EO-A22X	UCEC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.8244
p.R98H	DO43907	UCEC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.8244
p.R95M	TCGA-F7-7848	HNSC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.2778
p.R95M	DO14198	HNSC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.2778
p.D112Y	TCGA-KU-A66S	HNSC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.1389
p.D112Y	DO44456	HNSC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.1389
p.K80T	DO225089	BRCA	ICGC	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation blocking ubiquitination signal	0.6667
p.I69F	DO1125	BRCA	ICGC	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation altering degron motif	0.7415
p.S78I	DO229022	LICA	ICGC	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation blocking phosphorylation signal	0.7222
p.R98G	SIDM00101	Mesothelioma	GDSC	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.7568
p.R98G	ACH-002126	Lung Cancer	CCLE	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.7568
p.R98G	H2591	pleura	COSMIC	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.7568
p.V59I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation rewiring degron network	0.0556
p.V59I	ACH-001127	Leukemia	CCLE	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation rewiring degron network	0.0556
p.V59I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ILATPLPE	DEG_SCF_FBW7_2	69:76	Mutation rewiring degron network	0.0556
p.R96G	H2591	pleura	COSMIC	IRLQLKAIE	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.3056

Kaplan plot for STX4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STX4

UniProt ID: Q12846

Entrez ID: 6810

Protein name: Syntaxin-4 (Renal carcinoma antigen NY-REN-31)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STX4 in