DegronMD

Uniprot ID: Q12846

Source protein: Syntaxin-4

Source gene: STX4

Class: DEG_APCC_DBOX_1

Location: 97:105

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9009

ASA_SCORE: 67.6444

COIL: 0.0413

CONS_SCORE: 0.4619

DSS_SCORE: 0.4207

HELIX: 0.9604

FCONS_SCORE: 1.4454

RIG_SCORE: 0.7867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E113D	TCGA-BK-A6W3	UCEC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	0.1111
p.E113D	DO50076	UCEC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	0.1111
p.R98H	TCGA-EO-A22X	UCEC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	0.8244
p.R98H	DO43907	UCEC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	0.8244
p.R95M	TCGA-F7-7848	HNSC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	0.2778
p.R95M	DO14198	HNSC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	0.2778
p.D112Y	TCGA-KU-A66S	HNSC	TCGA	IRLQLKAIE	DEG_APCC_DBOX_1	0.1389
p.D112Y	DO44456	HNSC	ICGC	IRLQLKAIE	DEG_APCC_DBOX_1	0.1389
p.R98G	SIDM00101	Mesothelioma	GDSC	IRLQLKAIE	DEG_APCC_DBOX_1	0.7568
p.R98G	ACH-002126	Lung Cancer	CCLE	IRLQLKAIE	DEG_APCC_DBOX_1	0.7568
p.R98G	H2591	pleura	COSMIC	IRLQLKAIE	DEG_APCC_DBOX_1	0.7568
p.R96G	H2591	pleura	COSMIC	IRLQLKAIE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12846	Syntaxin-4	DEG_APCC_DBOX_1	97:105	IRLQLKAIE	APC,CDC20,FZR1	0.9009	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons