DegronMD

Uniprot ID: P29401

Source protein: Transketolase

Source gene: TKT

Class: DEG_SCF_FBW7_2

Location: 284:291

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 78.8125

COIL: 0.7791

CONS_SCORE: 0.2733

DSS_SCORE: 0.5287

HELIX: 0.1808

FCONS_SCORE: 1.0771

RIG_SCORE: 0.698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L293M	TCGA-A5-A0G1	UCEC	TCGA	ILATPPQE	DEG_SCF_FBW7_2	0.2778
p.Q280E	TCGA-D6-A6EM	HNSC	TCGA	ILATPPQE	DEG_SCF_FBW7_2	0.6667
p.T295I	TCGA-ER-A42L	SKCM	TCGA	ILATPPQE	DEG_SCF_FBW7_2	0.6667
p.G275R	DO48411	BLCA	ICGC	ILATPPQE	DEG_SCF_FBW7_2	0.5278
p.G282D	DO48523	KIRP	ICGC	ILATPPQE	DEG_SCF_FBW7_2	0.7222
p.F280I	SW684	soft_tissue	COSMIC	ILATPPQE	DEG_SCF_FBW7_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29401	Transketolase	DEG_SCF_FBW7_2	284:291	ILATPPQE	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons