DegronMD

Uniprot ID: Q8NBT3

Source protein: Transmembrane protein 145

Source gene: TMEM145

Class: LIG_APCC_ABBA_1

Location: 72:77

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5166

ASA_SCORE: 20.9833

COIL: 0.2742

CONS_SCORE: 0.5703

DSS_SCORE: 0.0468

HELIX: 0.0302

FCONS_SCORE: 1.5905

RIG_SCORE: 0.9326

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E65K	TCGA-4Z-AA7R	BLCA	TCGA	ILLYFD	LIG_APCC_ABBA_1	0.1389
p.E65K	DO51866	BLCA	ICGC	ILLYFD	LIG_APCC_ABBA_1	0.1389
p.R62H	TCGA-5M-AAT6	COAD	TCGA	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.R62H	DO223703	COAD	ICGC	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.R62H	SIDM00826	Colorectal Carcinoma	GDSC	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.R62H	ACH-001039	Colon/Colorectal Cancer	CCLE	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.R62H	COLO-205	large_intestine	COSMIC	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.L73I	TCGA-AP-A0LM	UCEC	TCGA	ILLYFD	LIG_APCC_ABBA_1	0.6063
p.R62C	TCGA-CG-4460	STAD	TCGA	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.R62C	DO38427	STAD	ICGC	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.R62L	DO229009	LICA	ICGC	ILLYFD	LIG_APCC_ABBA_1	0.0556
p.L83I	DO43306	UCEC	ICGC	ILLYFD	LIG_APCC_ABBA_1	0.1667
p.P79T	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	ILLYFD	LIG_APCC_ABBA_1	0.2778
p.P79T	ACH-002062	Lymphoma	CCLE	ILLYFD	LIG_APCC_ABBA_1	0.2778
p.P79T	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	ILLYFD	LIG_APCC_ABBA_1	0.2778
p.C69R	SIDM00151	Ovarian Carcinoma	GDSC	ILLYFD	LIG_APCC_ABBA_1	0.25
p.C69R	ACH-000966	Ovarian Cancer	CCLE	ILLYFD	LIG_APCC_ABBA_1	0.25
p.C69R	IGROV-1	ovary	COSMIC	ILLYFD	LIG_APCC_ABBA_1	0.25
p.C79R	IGROV-1	ovary	COSMIC	ILLYFD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBT3	Transmembrane protein 145	LIG_APCC_ABBA_1	72:77	ILLYFD	APC,CDC20,FZR1	0.5166	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons