DegronMD - Q8NBT3(TMEM145)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R482L	TCGA-21-1077	LUSC	TCGA	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation altering degron motif	0.7316
p.R482L	DO26725	LUSC	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation altering degron motif	0.7316
p.R471Q	TCGA-4Z-AA7M	BLCA	TCGA	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.1389
p.R471Q	DO218976	BLCA	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.1389
p.E65K	TCGA-4Z-AA7R	BLCA	TCGA	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.1389
p.E65K	DO51866	BLCA	ICGC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.1389
p.R62H	TCGA-5M-AAT6	COAD	TCGA	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.R62H	DO223703	COAD	ICGC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.R62H	SIDM00826	Colorectal Carcinoma	GDSC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.R62H	ACH-001039	Colon/Colorectal Cancer	CCLE	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.R62H	COLO-205	large intestine	COSMIC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.L73I	TCGA-AP-A0LM	UCEC	TCGA	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation altering degron motif	0.6063
p.R482H	TCGA-BR-8078	STAD	TCGA	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation altering degron motif	0.7133
p.R482H	DO38288	STAD	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation altering degron motif	0.7133
p.R62C	TCGA-CG-4460	STAD	TCGA	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.R62C	DO38427	STAD	ICGC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.R491G	TCGA-DK-A3WW	BLCA	TCGA	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.1111
p.R491G	DO481	BLCA	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.1111
p.S476F	TCGA-EO-A22R	UCEC	TCGA	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.2778
p.S476F	DO42713	UCEC	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.2778
p.P487H	TCGA-FS-A1ZB	SKCM	TCGA	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.2222
p.P487H	DO37886	SKCM	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.2222
p.R485W	TCGA-OD-A75X	SKCM	TCGA	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.2778
p.R485W	DO48601	SKCM	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation rewiring degron network	0.2778
p.R62L	DO229009	LICA	ICGC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.0556
p.L83I	DO43306	UCEC	ICGC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.1667
p.V479A	DO42256	UCEC	ICGC	LPLFRD	LIG_APCC_ABBA_1	478:483	Mutation altering degron motif	0.6936
p.P79T	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.2778
p.P79T	ACH-002062	Lymphoma	CCLE	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.2778
p.P79T	SLVL	haematopoietic and lymphoid tissue	COSMIC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.2778
p.C69R	SIDM00151	Ovarian Carcinoma	GDSC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.25
p.C69R	ACH-000966	Ovarian Cancer	CCLE	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.25
p.C69R	IGROV-1	ovary	COSMIC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.25
p.C79R	IGROV-1	ovary	COSMIC	ILLYFD	LIG_APCC_ABBA_1	72:77	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM145

UniProt ID: Q8NBT3

Entrez ID: 284339

Protein name: Transmembrane protein 145

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM145 in