DegronMD

Uniprot ID: Q8NBT3

Source protein: Transmembrane protein 145

Source gene: TMEM145

Class: LIG_APCC_ABBA_1

Location: 478:483

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7263

ASA_SCORE: 89.2833

COIL: 0.8012

CONS_SCORE: 0.2204

DSS_SCORE: 0.5716

HELIX: 0.1542

FCONS_SCORE: 1.0116

RIG_SCORE: 0.7219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R482L	TCGA-21-1077	LUSC	TCGA	LPLFRD	LIG_APCC_ABBA_1	0.7316
p.R482L	DO26725	LUSC	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.7316
p.R471Q	TCGA-4Z-AA7M	BLCA	TCGA	LPLFRD	LIG_APCC_ABBA_1	0.1389
p.R471Q	DO218976	BLCA	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.1389
p.R482H	TCGA-BR-8078	STAD	TCGA	LPLFRD	LIG_APCC_ABBA_1	0.7133
p.R482H	DO38288	STAD	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.7133
p.R491G	TCGA-DK-A3WW	BLCA	TCGA	LPLFRD	LIG_APCC_ABBA_1	0.1111
p.R491G	DO481	BLCA	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.1111
p.S476F	TCGA-EO-A22R	UCEC	TCGA	LPLFRD	LIG_APCC_ABBA_1	0.2778
p.S476F	DO42713	UCEC	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.2778
p.P487H	TCGA-FS-A1ZB	SKCM	TCGA	LPLFRD	LIG_APCC_ABBA_1	0.2222
p.P487H	DO37886	SKCM	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.2222
p.R485W	TCGA-OD-A75X	SKCM	TCGA	LPLFRD	LIG_APCC_ABBA_1	0.2778
p.R485W	DO48601	SKCM	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.2778
p.V479A	DO42256	UCEC	ICGC	LPLFRD	LIG_APCC_ABBA_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBT3	Transmembrane protein 145	LIG_APCC_ABBA_1	478:483	LPLFRD	APC,CDC20,FZR1	0.7263	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons