DegronMD

Uniprot ID: Q6FHJ7

Source protein: Secreted frizzled-related protein 4

Source gene: SFRP4

Class: LIG_APCC_ABBA_1

Location: 248:253

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.634

ASA_SCORE: 78.2333

COIL: 0.7353

CONS_SCORE: 0.616

DSS_SCORE: 0.03

HELIX: 0.0173

FCONS_SCORE: 0.9084

RIG_SCORE: 0.8583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S241C	TCGA-A8-A09G	BRCA	TCGA	ILPHQD	LIG_APCC_ABBA_1	0.1389
p.S241C	DO1990	BRCA	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.1389
p.S241Y	TCGA-AP-A056	UCEC	TCGA	ILPHQD	LIG_APCC_ABBA_1	0.1389
p.S241Y	TCGA-BS-A0UV	UCEC	TCGA	ILPHQD	LIG_APCC_ABBA_1	0.1389
p.S241Y	DO42793	UCEC	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.1389
p.S241Y	DO43971	UCEC	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.1389
p.R262H	TCGA-B5-A11E	UCEC	TCGA	ILPHQD	LIG_APCC_ABBA_1	0.0833
p.R262H	TCGA-HD-7832	HNSC	TCGA	ILPHQD	LIG_APCC_ABBA_1	0.0833
p.R262H	DO16061	HNSC	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.0833
p.R262H	DO41644	UCEC	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.0833
p.R262C	TCGA-N9-A4Q7	UCS	TCGA	ILPHQD	LIG_APCC_ABBA_1	0.0833
p.R262S	DO229019	LICA	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.0833
p.P246Q	DO229022	LICA	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.2778
p.P246S	DO231057	LUSC	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.2778
p.S241F	DO222363	MELA	ICGC	ILPHQD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6FHJ7	Secreted frizzled-related protein 4	LIG_APCC_ABBA_1	248:253	ILPHQD	APC,CDC20,FZR1	0.634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons