DegronMD

Uniprot ID: Q6AI12

Source protein: Ankyrin repeat domain-containing protein 40

Source gene: ANKRD40

Class: DEG_SCF_FBW7_1

Location: 196:203

E3 ligase: FBXW7

DEGRON score: 0.9885

ASA_SCORE: 76.875

COIL: 0.7546

CONS_SCORE: 0.3089

DSS_SCORE: 0.6102

HELIX: 0.0778

FCONS_SCORE: 0.8992

RIG_SCORE: 0.6704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P207S	TCGA-D7-6518	STAD	TCGA	ILRTPEST	DEG_SCF_FBW7_1	0.2222
p.P207S	DO38519	STAD	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.2222
p.P207S	ACH-001567	Skin Cancer	CCLE	ILRTPEST	DEG_SCF_FBW7_1	0.2222
p.A195T	TCGA-EO-A22U	UCEC	TCGA	ILRTPEST	DEG_SCF_FBW7_1	0.3056
p.A195T	DO43755	UCEC	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.3056
p.V190A	DO228974	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.1667
p.T199K	DO228976	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.8417
p.P207H	DO229019	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.2222
p.P200T	DO229026	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.7031
p.P205T	DO229041	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.2778
p.P211T	DO229009	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	0.1111
p.V213M	SIDM01617	Endometrial Carcinoma	GDSC	ILRTPEST	DEG_SCF_FBW7_1	0.0556
p.V213M	ACH-000994	Endometrial/Uterine Cancer	CCLE	ILRTPEST	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6AI12	Ankyrin repeat domain-containing protein 40	DEG_SCF_FBW7_1	196:203	ILRTPEST	FBXW7	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons