DegronMD - Q6AI12(ANKRD40)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P148L	TCGA-22-1016	LUSC	TCGA	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation altering degron motif	0.6471
p.P148L	DO26971	LUSC	ICGC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation altering degron motif	0.6471
p.I132M	TCGA-75-6214	LUAD	TCGA	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation altering degron motif	0.6507
p.I132M	DO24830	LUAD	ICGC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation altering degron motif	0.6507
p.P127T	TCGA-A6-A565	COAD	TCGA	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.1944
p.P127T	DO44090	COAD	ICGC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.1944
p.P207S	TCGA-D7-6518	STAD	TCGA	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.2222
p.P207S	DO38519	STAD	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.2222
p.P207S	ACH-001567	Skin Cancer	CCLE	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.2222
p.T134A	TCGA-EE-A181	SKCM	TCGA	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation altering degron motif	0.7139
p.T134A	DO37444	SKCM	ICGC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation altering degron motif	0.7139
p.A195T	TCGA-EO-A22U	UCEC	TCGA	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.3056
p.A195T	DO43755	UCEC	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.3056
p.M143I	TCGA-YC-A89H	BLCA	TCGA	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.1944
p.M143I	TCGA-YC-A89H	BLCA	TCGA	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.1944
p.M143I	DO51948	BLCA	ICGC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.1944
p.M143I	DO51948	BLCA	ICGC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.1944
p.P152S	TCGA-YD-A9TA	SKCM	TCGA	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation altering degron motif	0.5641
p.P152S	DO219503	SKCM	ICGC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation altering degron motif	0.5641
p.Y133C	DO222518	ESCA	ICGC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation altering degron motif	0.5976
p.Y133C	DO46730	PACA	ICGC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation altering degron motif	0.5976
p.V190A	DO228974	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1667
p.T199K	DO228976	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.8417
p.P207H	DO229019	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.2222
p.P200T	DO229026	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.7031
p.P205T	DO229041	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.2778
p.P211T	DO229009	LICA	ICGC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1111
p.M143L	DO231155	LUSC	ICGC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.1944
p.M143L	DO231155	LUSC	ICGC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.1944
p.D139A	SIDM00299	Other Sarcomas	GDSC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.0833
p.D139A	SIDM00299	Other Sarcomas	GDSC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.3056
p.D139A	SIDM00579	Neuroblastoma	GDSC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.0833
p.D139A	SIDM00579	Neuroblastoma	GDSC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.3056
p.D139A	ACH-002271	Sarcoma	CCLE	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.0833
p.D139A	ACH-002271	Sarcoma	CCLE	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.3056
p.D139A	ACH-002277	Neuroblastoma	CCLE	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.0833
p.D139A	ACH-002277	Neuroblastoma	CCLE	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.3056
p.D139A	NB(TU)1-10	autonomic ganglia	COSMIC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.0833
p.D139A	NB(TU)1-10	autonomic ganglia	COSMIC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.3056
p.D139A	MFH-ino	soft tissue	COSMIC	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation rewiring degron network	0.0833
p.D139A	MFH-ino	soft tissue	COSMIC	IYTPTAE	DEG_SCF_FBW7_2	132:138	Mutation rewiring degron network	0.3056
p.V213M	SIDM01617	Endometrial Carcinoma	GDSC	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.0556
p.V213M	ACH-000994	Endometrial/Uterine Cancer	CCLE	ILRTPEST	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.0556
p.P152H	ACH-000928	Endometrial/Uterine Cancer	CCLE	PSTPPAS	DEG_SCF_FBW7_1	148:154	Mutation altering degron motif	0.6583

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD40

UniProt ID: Q6AI12

Entrez ID: 91369

Protein name: Ankyrin repeat domain-containing protein 40

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD40 in