DegronMD

Uniprot ID: Q6AI12

Source protein: Ankyrin repeat domain-containing protein 40

Source gene: ANKRD40

Class: DEG_SCF_FBW7_2

Location: 132:138

E3 ligase: FBXW7

DEGRON score: 0.7593

ASA_SCORE: 57.4286

COIL: 0.6831

CONS_SCORE: 0.3526

DSS_SCORE: 0.5505

HELIX: 0.2083

FCONS_SCORE: 0.6416

RIG_SCORE: 0.7695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I132M	TCGA-75-6214	LUAD	TCGA	IYTPTAE	DEG_SCF_FBW7_2	0.6507
p.I132M	DO24830	LUAD	ICGC	IYTPTAE	DEG_SCF_FBW7_2	0.6507
p.P127T	TCGA-A6-A565	COAD	TCGA	IYTPTAE	DEG_SCF_FBW7_2	0.1944
p.P127T	DO44090	COAD	ICGC	IYTPTAE	DEG_SCF_FBW7_2	0.1944
p.T134A	TCGA-EE-A181	SKCM	TCGA	IYTPTAE	DEG_SCF_FBW7_2	0.7139
p.T134A	DO37444	SKCM	ICGC	IYTPTAE	DEG_SCF_FBW7_2	0.7139
p.M143I	TCGA-YC-A89H	BLCA	TCGA	IYTPTAE	DEG_SCF_FBW7_2	0.1944
p.M143I	DO51948	BLCA	ICGC	IYTPTAE	DEG_SCF_FBW7_2	0.1944
p.Y133C	DO222518	ESCA	ICGC	IYTPTAE	DEG_SCF_FBW7_2	0.5976
p.Y133C	DO46730	PACA	ICGC	IYTPTAE	DEG_SCF_FBW7_2	0.5976
p.M143L	DO231155	LUSC	ICGC	IYTPTAE	DEG_SCF_FBW7_2	0.1944
p.D139A	SIDM00299	Other Sarcomas	GDSC	IYTPTAE	DEG_SCF_FBW7_2	0.3056
p.D139A	SIDM00579	Neuroblastoma	GDSC	IYTPTAE	DEG_SCF_FBW7_2	0.3056
p.D139A	ACH-002271	Sarcoma	CCLE	IYTPTAE	DEG_SCF_FBW7_2	0.3056
p.D139A	ACH-002277	Neuroblastoma	CCLE	IYTPTAE	DEG_SCF_FBW7_2	0.3056
p.D139A	NB(TU)1-10	autonomic_ganglia	COSMIC	IYTPTAE	DEG_SCF_FBW7_2	0.3056
p.D139A	MFH-ino	soft_tissue	COSMIC	IYTPTAE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6AI12	Ankyrin repeat domain-containing protein 40	DEG_SCF_FBW7_2	132:138	IYTPTAE	FBXW7	0.7593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons