DegronMD

Uniprot ID: Q6AI12

Source protein: Ankyrin repeat domain-containing protein 40

Source gene: ANKRD40

Class: DEG_SCF_FBW7_1

Location: 148:154

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 55.9857

COIL: 0.9239

CONS_SCORE: 0.4068

DSS_SCORE: 0.8526

HELIX: 0.0201

FCONS_SCORE: 1.1272

RIG_SCORE: 0.4797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P148L	TCGA-22-1016	LUSC	TCGA	PSTPPAS	DEG_SCF_FBW7_1	0.6471
p.P148L	DO26971	LUSC	ICGC	PSTPPAS	DEG_SCF_FBW7_1	0.6471
p.M143I	TCGA-YC-A89H	BLCA	TCGA	PSTPPAS	DEG_SCF_FBW7_1	0.1944
p.M143I	DO51948	BLCA	ICGC	PSTPPAS	DEG_SCF_FBW7_1	0.1944
p.P152S	TCGA-YD-A9TA	SKCM	TCGA	PSTPPAS	DEG_SCF_FBW7_1	0.5641
p.P152S	DO219503	SKCM	ICGC	PSTPPAS	DEG_SCF_FBW7_1	0.5641
p.M143L	DO231155	LUSC	ICGC	PSTPPAS	DEG_SCF_FBW7_1	0.1944
p.D139A	SIDM00299	Other Sarcomas	GDSC	PSTPPAS	DEG_SCF_FBW7_1	0.0833
p.D139A	SIDM00579	Neuroblastoma	GDSC	PSTPPAS	DEG_SCF_FBW7_1	0.0833
p.D139A	ACH-002271	Sarcoma	CCLE	PSTPPAS	DEG_SCF_FBW7_1	0.0833
p.D139A	ACH-002277	Neuroblastoma	CCLE	PSTPPAS	DEG_SCF_FBW7_1	0.0833
p.D139A	NB(TU)1-10	autonomic_ganglia	COSMIC	PSTPPAS	DEG_SCF_FBW7_1	0.0833
p.D139A	MFH-ino	soft_tissue	COSMIC	PSTPPAS	DEG_SCF_FBW7_1	0.0833
p.P152H	ACH-000928	Endometrial/Uterine Cancer	CCLE	PSTPPAS	DEG_SCF_FBW7_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6AI12	Ankyrin repeat domain-containing protein 40	DEG_SCF_FBW7_1	148:154	PSTPPAS	FBXW7	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons