DegronMD

Uniprot ID: Q7L5N7

Source protein: Lysophosphatidylcholine acyltransferase 2

Source gene: LPCAT2

Class: LIG_APCC_ABBA_1

Location: 215:220

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7364

ASA_SCORE: 48.0333

COIL: 0.6033

CONS_SCORE: 0.7684

DSS_SCORE: 0.328

HELIX: 0.0377

FCONS_SCORE: 1.3788

RIG_SCORE: 0.8777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I230F	TCGA-A6-6780	COAD	TCGA	ILVFPE	LIG_APCC_ABBA_1	0.0556
p.I230F	DO10244	COAD	ICGC	ILVFPE	LIG_APCC_ABBA_1	0.0556
p.S208T	TCGA-D8-A1XK	BRCA	TCGA	ILVFPE	LIG_APCC_ABBA_1	0.1389
p.S208T	DO4749	BRCA	ICGC	ILVFPE	LIG_APCC_ABBA_1	0.1389
p.W212L	TCGA-DA-A1I1	SKCM	TCGA	ILVFPE	LIG_APCC_ABBA_1	0.25
p.W212L	DO37966	SKCM	ICGC	ILVFPE	LIG_APCC_ABBA_1	0.25
p.R226C	TCGA-DA-A95X	SKCM	TCGA	ILVFPE	LIG_APCC_ABBA_1	0.1667
p.R226C	DO219480	SKCM	ICGC	ILVFPE	LIG_APCC_ABBA_1	0.1667
p.S208P	TCGA-FI-A2D6	UCEC	TCGA	ILVFPE	LIG_APCC_ABBA_1	0.1389
p.S208P	DO43867	UCEC	ICGC	ILVFPE	LIG_APCC_ABBA_1	0.1389
p.W212C	DO229045	LICA	ICGC	ILVFPE	LIG_APCC_ABBA_1	0.25
p.T206I	DO231127	LUSC	ICGC	ILVFPE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L5N7	Lysophosphatidylcholine acyltransferase 2	LIG_APCC_ABBA_1	215:220	ILVFPE	APC,CDC20,FZR1	0.7364	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons