DegronMD

Uniprot ID: O75937

Source protein: DnaJ homolog subfamily C member 8

Source gene: DNAJC8

Class: LIG_APCC_ABBA_1

Location: 82:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8874

ASA_SCORE: 71.2

COIL: 0.5185

CONS_SCORE: 0.7837

DSS_SCORE: 0.3944

HELIX: 0.4773

FCONS_SCORE: 1.2096

RIG_SCORE: 0.7674

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I82T	TCGA-BR-8059	STAD	TCGA	ILVHPD	LIG_APCC_ABBA_1	0.7078
p.I82T	DO38443	STAD	ICGC	ILVHPD	LIG_APCC_ABBA_1	0.7078
p.P86S	TCGA-EE-A3AC	SKCM	TCGA	ILVHPD	LIG_APCC_ABBA_1	0.5641
p.P86S	DO37631	SKCM	ICGC	ILVHPD	LIG_APCC_ABBA_1	0.5641
p.K88T	TCGA-CA-6717	COAD	TCGA	ILVHPD	LIG_APCC_ABBA_1	0.3056
p.K88T	DO8264	COAD	ICGC	ILVHPD	LIG_APCC_ABBA_1	0.3056
p.R78W	TCGA-AA-A010	COAD	TCGA	ILVHPD	LIG_APCC_ABBA_1	0.2222
p.R78W	TCGA-BR-8591	STAD	TCGA	ILVHPD	LIG_APCC_ABBA_1	0.2222
p.R78W	DO232761	PBCA	ICGC	ILVHPD	LIG_APCC_ABBA_1	0.2222
p.R78W	DO47973	STAD	ICGC	ILVHPD	LIG_APCC_ABBA_1	0.2222
p.R76S	TCGA-NH-A5IV	COAD	TCGA	ILVHPD	LIG_APCC_ABBA_1	0.1667
p.R76S	DO49095	COAD	ICGC	ILVHPD	LIG_APCC_ABBA_1	0.1667

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75937	DnaJ homolog subfamily C member 8	LIG_APCC_ABBA_1	82:87	ILVHPD	APC,CDC20,FZR1	0.8874	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons