DegronMD

Uniprot ID: Q6P0N0

Source protein: Mis18-binding protein 1

Source gene: MIS18BP1

Class: DEG_SCF_FBW7_1

Location: 650:657

E3 ligase: FBXW7

DEGRON score: 0.9761

ASA_SCORE: 91.5125

COIL: 0.7463

CONS_SCORE: 0.4663

DSS_SCORE: 0.1204

HELIX: 0.0741

FCONS_SCORE: 1.2501

RIG_SCORE: 0.8918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K646N	TCGA-MV-A51V	BLCA	TCGA	ILVTPLKS	DEG_SCF_FBW7_1	0.6667
p.K646N	DO474	BLCA	ICGC	ILVTPLKS	DEG_SCF_FBW7_1	0.6667
p.A642D	DO228985	LICA	ICGC	ILVTPLKS	DEG_SCF_FBW7_1	0.1111
p.A642D	DO229037	LICA	ICGC	ILVTPLKS	DEG_SCF_FBW7_1	0.1111
p.L651I	DO222653	MELA	ICGC	ILVTPLKS	DEG_SCF_FBW7_1	0.6063
p.P654L	DO218900	SKCA	ICGC	ILVTPLKS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P0N0	Mis18-binding protein 1	DEG_SCF_FBW7_1	650:657	ILVTPLKS	FBXW7	0.9761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons