DegronMD

Uniprot ID: O75815

Source protein: Breast cancer anti-estrogen resistance protein 3

Source gene: BCAR3

Class: DEG_SCF_SKP2-CKS1_1

Location: 126:133

E3 ligase: SKP2,CSK1

DEGRON score: 0.9248

ASA_SCORE: 88.425

COIL: 0.5459

CONS_SCORE: 0.4091

DSS_SCORE: 0.3895

HELIX: 0.4341

FCONS_SCORE: 1.1058

RIG_SCORE: 0.7758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D128N	TCGA-A2-A0CP	BRCA	TCGA	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D128N	DO2563	BRCA	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.6932
p.L143F	TCGA-AP-A0LM	UCEC	TCGA	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.L143F	DO43306	UCEC	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.K133N	TCGA-EO-A2CH	UCEC	TCGA	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.6918
p.K133N	DO40840	UCEC	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.6918
p.S124L	DO51882	BLCA	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E132D	DO10172	COAD	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.5647
p.E132D	DO7801	COAD	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.5647
p.S121F	SIDM00545	Melanoma	GDSC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S121F	ACH-000987	Skin Cancer	CCLE	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S121F	Mewo	skin	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1944
p.R118K	MFE-319	endometrium	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.R123H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.25
p.R141H	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75815	Breast cancer anti-estrogen resistance protein 3	DEG_SCF_SKP2-CKS1_1	126:133	IMDRTPEK	SKP2,CSK1	0.9248	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons