DegronMD - O75815(BCAR3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D128N	TCGA-A2-A0CP	BRCA	TCGA	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation altering degron motif	0.6932
p.D128N	DO2563	BRCA	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation altering degron motif	0.6932
p.L143F	TCGA-AP-A0LM	UCEC	TCGA	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.0556
p.L143F	DO43306	UCEC	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.0556
p.P517H	TCGA-AX-A3G8	UCEC	TCGA	VTPLLE	DEG_SCF_FBW7_2	505:510	Mutation rewiring degron network	0.1389
p.P517H	DO41014	UCEC	ICGC	VTPLLE	DEG_SCF_FBW7_2	505:510	Mutation rewiring degron network	0.1389
p.K133N	TCGA-EO-A2CH	UCEC	TCGA	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation altering degron motif	0.6918
p.K133N	DO40840	UCEC	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation altering degron motif	0.6918
p.Q498P	TCGA-UZ-A9PS	KIRP	TCGA	VTPLLE	DEG_SCF_FBW7_2	505:510	Mutation rewiring degron network	0.1389
p.Q498P	DO219709	KIRP	ICGC	VTPLLE	DEG_SCF_FBW7_2	505:510	Mutation rewiring degron network	0.1389
p.S124L	DO51882	BLCA	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.2778
p.E132D	DO10172	COAD	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation altering degron motif	0.5647
p.E132D	DO7801	COAD	ICGC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation altering degron motif	0.5647
p.T506K	DO229006	LICA	ICGC	VTPLLE	DEG_SCF_FBW7_2	505:510	Mutation altering degron motif	0.7306
p.S121F	SIDM00545	Melanoma	GDSC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.1944
p.S121F	ACH-000987	Skin Cancer	CCLE	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.1944
p.S121F	Mewo	skin	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.1944
p.N512H	SF539	central nervous system	COSMIC	VTPLLE	DEG_SCF_FBW7_2	505:510	Mutation rewiring degron network	0.2778
p.R118K	MFE-319	endometrium	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.1111
p.R123H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.25
p.R141H	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	IMDRTPEK	DEG_SCF_SKP2-CKS1_1	126:133	Mutation rewiring degron network	0.1111

Kaplan plot for BCAR3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCAR3

UniProt ID: O75815

Entrez ID: 8412

Protein name: Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCAR3 in