DegronMD

Uniprot ID: O75815

Source protein: Breast cancer anti-estrogen resistance protein 3

Source gene: BCAR3

Class: DEG_SCF_FBW7_2

Location: 505:510

E3 ligase: FBXW7

DEGRON score: 0.5033

ASA_SCORE: 60.3667

COIL: 0.6272

CONS_SCORE: 0.4988

DSS_SCORE: 0.429

HELIX: 0.0872

FCONS_SCORE: 1.1345

RIG_SCORE: 0.797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P517H	TCGA-AX-A3G8	UCEC	TCGA	VTPLLE	DEG_SCF_FBW7_2	0.1389
p.P517H	DO41014	UCEC	ICGC	VTPLLE	DEG_SCF_FBW7_2	0.1389
p.Q498P	TCGA-UZ-A9PS	KIRP	TCGA	VTPLLE	DEG_SCF_FBW7_2	0.1389
p.Q498P	DO219709	KIRP	ICGC	VTPLLE	DEG_SCF_FBW7_2	0.1389
p.T506K	DO229006	LICA	ICGC	VTPLLE	DEG_SCF_FBW7_2	0.7306
p.N512H	SF539	central_nervous_system	COSMIC	VTPLLE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75815	Breast cancer anti-estrogen resistance protein 3	DEG_SCF_FBW7_2	505:510	VTPLLE	FBXW7	0.5033	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons