DegronMD

Uniprot ID: Q9NNW5

Source protein: WD repeat-containing protein 6

Source gene: WDR6

Class: DEG_SCF_FBW7_1

Location: 816:823

E3 ligase: FBXW7

DEGRON score: 0.9261

ASA_SCORE: 54.4

COIL: 0.5399

CONS_SCORE: 0.2693

DSS_SCORE: 0.3569

HELIX: 0.0164

FCONS_SCORE: 0.745

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V832M	TCGA-49-AARE	LUAD	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	0.0833
p.S806L	TCGA-BH-A0HF	BRCA	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	0.0556
p.G827D	TCGA-D3-A3C7	SKCM	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	0.2222
p.R808C	TCGA-L5-A8NS	ESCA	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	0.1111
p.R808C	SIDM00945	Colorectal Carcinoma	GDSC	IMVTPDPS	DEG_SCF_FBW7_1	0.1111
p.R808C	CL-34	large_intestine	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	0.1111
p.S823G	DO218990	BLCA	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.6993
p.R808Q	DO223732	CESC	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.1111
p.S823N	DO44090	COAD	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.7069
p.A829T	DO222737	COCA	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.1667
p.T824P	DO219881	SKCA	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.3056
p.P825S	DO37946	SKCM	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.2778
p.P825T	DO38075	SKCM	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.2778
p.H831Q	DO38623	STAD	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	0.1111
p.L828P	SIDM00945	Colorectal Carcinoma	GDSC	IMVTPDPS	DEG_SCF_FBW7_1	0.1944
p.L828P	CL-34	large_intestine	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	0.1944
p.V828M	MZ7-mel	skin	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	0.1944
p.P807R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	0.0833
p.D821A	BHY	upper_aerodigestive_tract	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	0.6682

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NNW5	WD repeat-containing protein 6	DEG_SCF_FBW7_1	816:823	IMVTPDPS	FBXW7	0.9261	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons