DegronMD - Q9NNW5(WDR6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V832M	TCGA-49-AARE	LUAD	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.0833
p.S970R	TCGA-AX-A2IN	UCEC	TCGA	LGTPSLT	DEG_SCF_FBW7_1	969:975	Mutation altering degron motif	0.7427
p.S806L	TCGA-BH-A0HF	BRCA	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.0556
p.D968N	TCGA-C5-A7CJ	CESC	TCGA	LGTPSLT	DEG_SCF_FBW7_1	969:975	Mutation rewiring degron network	0.3056
p.G827D	TCGA-D3-A3C7	SKCM	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.2222
p.R808C	TCGA-L5-A8NS	ESCA	TCGA	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1111
p.R808C	SIDM00945	Colorectal Carcinoma	GDSC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1111
p.R808C	CL-34	large intestine	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1111
p.S823G	DO218990	BLCA	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation altering degron motif	0.6993
p.R808Q	DO223732	CESC	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1111
p.N984T	DO9346	COAD	ICGC	LGTPSLT	DEG_SCF_FBW7_1	969:975	Mutation rewiring degron network	0.0833
p.S823N	DO44090	COAD	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation altering degron motif	0.7069
p.H979N	DO8312	COAD	ICGC	LGTPSLT	DEG_SCF_FBW7_1	969:975	Mutation rewiring degron network	0.2222
p.A829T	DO222737	COCA	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1667
p.T824P	DO219881	SKCA	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.3056
p.P825S	DO37946	SKCM	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.2778
p.P825T	DO38075	SKCM	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.2778
p.H831Q	DO38623	STAD	ICGC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1111
p.L962M	SIDM01307	Colorectal Carcinoma	GDSC	LGTPSLT	DEG_SCF_FBW7_1	969:975	Mutation rewiring degron network	0.1389
p.L828P	SIDM00945	Colorectal Carcinoma	GDSC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1944
p.L828P	CL-34	large intestine	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1944
p.V828M	MZ7-mel	skin	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.1944
p.P807R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation rewiring degron network	0.0833
p.D821A	BHY	upper aerodigestive tract	COSMIC	IMVTPDPS	DEG_SCF_FBW7_1	816:823	Mutation altering degron motif	0.6682

Kaplan plot for WDR6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR6

UniProt ID: Q9NNW5

Entrez ID: 11180

Protein name: WD repeat-containing protein 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR6 in