DegronMD

Uniprot ID: Q9NNW5

Source protein: WD repeat-containing protein 6

Source gene: WDR6

Class: DEG_SCF_FBW7_1

Location: 969:975

E3 ligase: FBXW7

DEGRON score: 0.9007

ASA_SCORE: 48.4857

COIL: 0.6067

CONS_SCORE: 0.2542

DSS_SCORE: 0.3603

HELIX: 0.0181

FCONS_SCORE: 0.6732

RIG_SCORE: 0.7278

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S970R	TCGA-AX-A2IN	UCEC	TCGA	LGTPSLT	DEG_SCF_FBW7_1	0.7427
p.D968N	TCGA-C5-A7CJ	CESC	TCGA	LGTPSLT	DEG_SCF_FBW7_1	0.3056
p.H979N	DO8312	COAD	ICGC	LGTPSLT	DEG_SCF_FBW7_1	0.2222
p.L962M	SIDM01307	Colorectal Carcinoma	GDSC	LGTPSLT	DEG_SCF_FBW7_1	0.1389
p.N984T	DO9346	COAD	ICGC	LGTPSLT	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NNW5	WD repeat-containing protein 6	DEG_SCF_FBW7_1	969:975	LGTPSLT	FBXW7	0.9007	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons