DegronMD

Uniprot ID: Q7Z7M9

Source protein: Polypeptide N-acetylgalactosaminyltransferase 5

Source gene: GALNT5

Class: DEG_SCF_FBW7_1

Location: 293:300

E3 ligase: FBXW7

DEGRON score: 0.9832

ASA_SCORE: 82.6625

COIL: 0.8609

CONS_SCORE: 0.3429

DSS_SCORE: 0.5739

HELIX: 0.071

FCONS_SCORE: 1.0559

RIG_SCORE: 0.6887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G309W	TCGA-AA-3947	COAD	TCGA	INETPLGS	DEG_SCF_FBW7_1	0.0833
p.G309W	DO8192	COAD	ICGC	INETPLGS	DEG_SCF_FBW7_1	0.0833
p.L301V	TCGA-DX-A2IZ	SARC	TCGA	INETPLGS	DEG_SCF_FBW7_1	0.3056
p.L301V	DO219961	SARC	ICGC	INETPLGS	DEG_SCF_FBW7_1	0.3056
p.L288S	TCGA-UY-A78K	BLCA	TCGA	INETPLGS	DEG_SCF_FBW7_1	0.1944
p.L288S	DO219031	BLCA	ICGC	INETPLGS	DEG_SCF_FBW7_1	0.1944
p.A310S	DO231174	LUSC	ICGC	INETPLGS	DEG_SCF_FBW7_1	0.0556
p.S292C	SIDM01043	Other Sarcomas	GDSC	INETPLGS	DEG_SCF_FBW7_1	0.75
p.S292C	ACH-000913	Endometrial/Uterine Cancer	CCLE	INETPLGS	DEG_SCF_FBW7_1	0.75
p.S292C	ESS-1	endometrium	COSMIC	INETPLGS	DEG_SCF_FBW7_1	0.75
p.R287H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	INETPLGS	DEG_SCF_FBW7_1	0.1667
p.R287H	ACH-000953	Leukemia	CCLE	INETPLGS	DEG_SCF_FBW7_1	0.1667
p.R287H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	INETPLGS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7M9	Polypeptide N-acetylgalactosaminyltransferase 5	DEG_SCF_FBW7_1	293:300	INETPLGS	FBXW7	0.9832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons