DegronMD - Q7Z7M9(GALNT5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G309W	TCGA-AA-3947	COAD	TCGA	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.G309W	DO8192	COAD	ICGC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0833
p.H81R	TCGA-AG-3906	READ	TCGA	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1667
p.H81R	DO36491	READ	ICGC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.1667
p.E89D	TCGA-AG-A002	READ	TCGA	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.6758
p.L301V	TCGA-DX-A2IZ	SARC	TCGA	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.L301V	DO219961	SARC	ICGC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.3056
p.L288S	TCGA-UY-A78K	BLCA	TCGA	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.L288S	DO219031	BLCA	ICGC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1944
p.K93N	DO222798	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2778
p.P77L	DO229010	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	DO229016	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	DO229003	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00961	Ewing's Sarcoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00303	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00305	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00450	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00353	Other Sarcomas	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00216	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00215	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00434	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01020	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00437	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00993	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00435	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01151	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00411	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00584	Osteosarcoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01199	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00607	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00370	T-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01005	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01242	Melanoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00465	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00589	Oral Cavity Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00002	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00571	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00417	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00040	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00260	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00492	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00568	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01196	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00619	Thyroid Gland Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01093	Cervical Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00556	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00487	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00360	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00489	Oral Cavity Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00488	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00365	Small Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00276	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00567	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00612	Glioma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00239	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00580	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00618	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00988	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00616	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01217	Other Blood Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00324	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00368	Small Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00560	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00241	Breast Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00289	B-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00579	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00603	Head and Neck Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00591	Oral Cavity Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00279	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00243	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00192	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01569	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00165	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01449	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01335	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01570	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01460	Glioma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01393	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00169	Head and Neck Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01578	Bladder Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01336	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00158	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01471	Chronic Myelogenous Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01347	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00248	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00161	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00163	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01447	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01433	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01658	Unknown	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00173	Head and Neck Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00959	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01753	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00016	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01451	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01442	Glioma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM00159	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01619	Endometrial Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01618	B-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.P77L	SIDM01443	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.A310S	DO231174	LUSC	ICGC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.0556
p.E89Q	DO231453	THCA	ICGC	GKENV	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.6744
p.S292C	SIDM01043	Other Sarcomas	GDSC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation blocking phosphorylation signal	0.75
p.S292C	ACH-000913	Endometrial/Uterine Cancer	CCLE	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation blocking phosphorylation signal	0.75
p.S292C	ESS-1	endometrium	COSMIC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation blocking phosphorylation signal	0.75
p.R287H	SIDM01154	T-Lymphoblastic Leukemia	GDSC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1667
p.R287H	ACH-000953	Leukemia	CCLE	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1667
p.R287H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	INETPLGS	DEG_SCF_FBW7_1	293:300	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GALNT5

UniProt ID: Q7Z7M9

Entrez ID: 11227

Protein name: Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GALNT5 in