DegronMD

Uniprot ID: Q7Z7M9

Source protein: Polypeptide N-acetylgalactosaminyltransferase 5

Source gene: GALNT5

Class: DEG_APCC_KENBOX_2

Location: 87:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9247

ASA_SCORE: 73.3

COIL: 0.5242

CONS_SCORE: 0.376

DSS_SCORE: 0.5015

HELIX: 0.4466

FCONS_SCORE: 1.1725

RIG_SCORE: 0.6974

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H81R	TCGA-AG-3906	READ	TCGA	GKENV	DEG_APCC_KENBOX_2	0.1667
p.H81R	DO36491	READ	ICGC	GKENV	DEG_APCC_KENBOX_2	0.1667
p.E89D	TCGA-AG-A002	READ	TCGA	GKENV	DEG_APCC_KENBOX_2	0.6758
p.K93N	DO222798	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.2778
p.P77L	DO229010	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	DO229016	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	DO229003	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00961	Ewing's Sarcoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00303	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00305	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00450	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00353	Other Sarcomas	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00216	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00215	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00434	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01020	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00437	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00993	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00435	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01151	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00411	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00584	Osteosarcoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01199	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00607	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00370	T-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01005	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01242	Melanoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00465	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00589	Oral Cavity Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00002	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00571	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00417	Plasma Cell Myeloma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00040	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00260	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00492	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00568	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01196	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00619	Thyroid Gland Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01093	Cervical Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00556	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00487	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00360	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00489	Oral Cavity Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00488	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00365	Small Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00276	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00567	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00612	Glioma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00239	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00580	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00618	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00988	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00616	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01217	Other Blood Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00324	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00368	Small Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00560	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00241	Breast Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00289	B-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00579	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00603	Head and Neck Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00591	Oral Cavity Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00279	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00243	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00192	Colorectal Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01569	Hepatocellular Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00165	Other Solid Cancers	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01449	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01335	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01570	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01460	Glioma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01393	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00169	Head and Neck Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01578	Bladder Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01336	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00158	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01471	Chronic Myelogenous Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01347	Ovarian Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00248	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00161	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00163	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01447	Glioblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01433	Kidney Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01658	Unknown	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00173	Head and Neck Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00959	Acute Myeloid Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01753	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00016	Neuroblastoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01451	Pancreatic Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01442	Glioma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM00159	Biliary Tract Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01619	Endometrial Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01618	B-Lymphoblastic Leukemia	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.P77L	SIDM01443	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.0556
p.E89Q	DO231453	THCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17027	Zinc finger protein 23	DEG_APCC_KENBOX_2	62:66	GKENV	APC,CDC20,FZR1	0.9286	More...
Q7Z7M9	Polypeptide N-acetylgalactosaminyltransferase 5	DEG_APCC_KENBOX_2	87:91	GKENV	APC,CDC20,FZR1	0.9247	More...
Q9H307	Pinin	DEG_APCC_KENBOX_2	445:449	GKENV	APC,CDC20,FZR1	0.5717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENV

Degron related mutations and impact score

Drug responses associated with GALNT5 mutations

All proteins holding degron of GKENV