DegronMD

Uniprot ID: P17027

Source protein: Zinc finger protein 23

Source gene: ZNF23

Class: DEG_APCC_KENBOX_2

Location: 62:66

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9286

ASA_SCORE: 97.24

COIL: 0.7266

CONS_SCORE: 0.4714

DSS_SCORE: 0.4686

HELIX: 0.137

FCONS_SCORE: 0.9788

RIG_SCORE: 0.7584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D73G	TCGA-17-Z045	LUAD	TCGA	GKENV	DEG_APCC_KENBOX_2	0.1389
p.D73N	TCGA-AA-3984	COAD	TCGA	GKENV	DEG_APCC_KENBOX_2	0.1389
p.D73N	TCGA-AX-A05Z	UCEC	TCGA	GKENV	DEG_APCC_KENBOX_2	0.1389
p.D73N	DO9002	COAD	ICGC	GKENV	DEG_APCC_KENBOX_2	0.1389
p.D73N	DO40884	UCEC	ICGC	GKENV	DEG_APCC_KENBOX_2	0.1389
p.E64D	TCGA-AN-A046	BRCA	TCGA	GKENV	DEG_APCC_KENBOX_2	0.6758
p.E64D	DO1285	BRCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6758
p.E64D	SIDM01611	Endometrial Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.6758
p.E64D	ACH-000996	Endometrial/Uterine Cancer	CCLE	GKENV	DEG_APCC_KENBOX_2	0.6758
p.N53S	TCGA-AX-A0J0	UCEC	TCGA	GKENV	DEG_APCC_KENBOX_2	0.0833
p.N53S	DO41133	UCEC	ICGC	GKENV	DEG_APCC_KENBOX_2	0.0833
p.R72I	TCGA-AX-A2HC	UCEC	TCGA	GKENV	DEG_APCC_KENBOX_2	0.1667
p.R72I	DO41572	UCEC	ICGC	GKENV	DEG_APCC_KENBOX_2	0.1667
p.R72T	TCGA-D6-A4ZB	HNSC	TCGA	GKENV	DEG_APCC_KENBOX_2	0.1667
p.R72T	DO44446	HNSC	ICGC	GKENV	DEG_APCC_KENBOX_2	0.1667
p.N53I	TCGA-DK-A1A7	BLCA	TCGA	GKENV	DEG_APCC_KENBOX_2	0.0833
p.N53I	DO483	BLCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.0833
p.G62A	DO218280	ORCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6429
p.D73Y	DO48915	PBCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.1389
p.D73V	DO48915	PBCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.1389
p.A67T	DO42673	UCEC	ICGC	GKENV	DEG_APCC_KENBOX_2	0.75
p.R72S	SIDM00383	Gastric Carcinoma	GDSC	GKENV	DEG_APCC_KENBOX_2	0.1667
p.R72S	ACH-002198	Gastric Cancer	CCLE	GKENV	DEG_APCC_KENBOX_2	0.1667
p.R72S	SCH	stomach	COSMIC	GKENV	DEG_APCC_KENBOX_2	0.1667
p.C73Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	GKENV	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17027	Zinc finger protein 23	DEG_APCC_KENBOX_2	62:66	GKENV	APC,CDC20,FZR1	0.9286	More...
Q7Z7M9	Polypeptide N-acetylgalactosaminyltransferase 5	DEG_APCC_KENBOX_2	87:91	GKENV	APC,CDC20,FZR1	0.9247	More...
Q9H307	Pinin	DEG_APCC_KENBOX_2	445:449	GKENV	APC,CDC20,FZR1	0.5717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons