DegronMD - Q9H307(PNN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D436H	TCGA-50-5066	LUAD	TCGA	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.0833
p.D436H	DO25040	LUAD	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation rewiring degron network	0.0833
p.V545A	TCGA-86-8672	LUAD	TCGA	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation rewiring degron network	0.3056
p.V545A	DO25434	LUAD	ICGC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation rewiring degron network	0.3056
p.A508S	TCGA-B5-A3FC	UCEC	TCGA	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.2778
p.A508S	DO41871	UCEC	ICGC	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.2778
p.S506L	TCGA-DF-A2KU	UCEC	TCGA	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.2222
p.S506L	DO223286	UCEC	ICGC	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.2222
p.S443F	TCGA-EO-A22U	UCEC	TCGA	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.7222
p.S443F	DO43755	UCEC	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.7222
p.K553N	DO48428	BLCA	ICGC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation rewiring degron network	0.2778
p.T441S	DO229010	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.6667
p.T441S	DO229013	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.6667
p.T441S	DO229016	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.6667
p.T441S	DO229003	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.6667
p.T441S	DO229005	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.6667
p.K553E	DO233270	GACA	ICGC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation rewiring degron network	0.2778
p.K437E	DO231758	LINC	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation substituting flanking lysine	0.2222
p.K536N	DO45094	LIRI	ICGC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation blocking ubiquitination signal	0.5
p.T441I	DO220876	MELA	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation blocking phosphorylation signal	0.6667
p.G521E	DO222647	MELA	ICGC	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.2222
p.N448K	DO222749	MELA	ICGC	GKENV	DEG_APCC_KENBOX_2	445:449	Mutation altering degron motif	0.6918
p.H549R	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation altering degron motif	0.8244
p.H549R	ACH-000534	Lymphoma	CCLE	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation altering degron motif	0.8244
p.H549R	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation altering degron motif	0.8244
p.V509L	SIDM01039	Other Solid Cancers	GDSC	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.3056
p.V509A	SIDM00213	Thyroid Gland Carcinoma	GDSC	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.3056
p.V509A	ACH-000903	Thyroid Cancer	CCLE	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.3056
p.V509A	FTC-133	thyroid	COSMIC	LQPTPQVT	DEG_SCF_FBW7_1	510:517	Mutation rewiring degron network	0.3056
p.H549P	SIDM01012	Other Blood Cancers	GDSC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation altering degron motif	0.7694
p.H549P	JVM-3	haematopoietic and lymphoid tissue	COSMIC	LTVHPE	LIG_APCC_ABBA_1	546:551	Mutation altering degron motif	0.7694

Kaplan plot for PNN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNN

UniProt ID: Q9H307

Entrez ID: 5411

Protein name: Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNN in