DegronMD

Uniprot ID: Q9H307

Source protein: Pinin

Source gene: PNN

Class: LIG_APCC_ABBA_1

Location: 546:551

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9927

ASA_SCORE: 108.1167

COIL: 0.929

CONS_SCORE: 0.18

DSS_SCORE: 0.588

HELIX: 0.0355

FCONS_SCORE: 0.9732

RIG_SCORE: 0.728

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V545A	TCGA-86-8672	LUAD	TCGA	LTVHPE	LIG_APCC_ABBA_1	0.3056
p.V545A	DO25434	LUAD	ICGC	LTVHPE	LIG_APCC_ABBA_1	0.3056
p.K553N	DO48428	BLCA	ICGC	LTVHPE	LIG_APCC_ABBA_1	0.2778
p.K553E	DO233270	GACA	ICGC	LTVHPE	LIG_APCC_ABBA_1	0.2778
p.K536N	DO45094	LIRI	ICGC	LTVHPE	LIG_APCC_ABBA_1	0.5
p.H549R	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTVHPE	LIG_APCC_ABBA_1	0.8244
p.H549R	ACH-000534	Lymphoma	CCLE	LTVHPE	LIG_APCC_ABBA_1	0.8244
p.H549R	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	LTVHPE	LIG_APCC_ABBA_1	0.8244
p.H549P	SIDM01012	Other Blood Cancers	GDSC	LTVHPE	LIG_APCC_ABBA_1	0.7694
p.H549P	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	LTVHPE	LIG_APCC_ABBA_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H307	Pinin	LIG_APCC_ABBA_1	546:551	LTVHPE	APC,CDC20,FZR1	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons