DegronMD

Uniprot ID: Q9H307

Source protein: Pinin

Source gene: PNN

Class: DEG_SCF_FBW7_1

Location: 510:517

E3 ligase: FBXW7

DEGRON score: 0.7575

ASA_SCORE: 98.1875

COIL: 0.8873

CONS_SCORE: 0.2011

DSS_SCORE: 0.5966

HELIX: 0.0644

FCONS_SCORE: 1.0359

RIG_SCORE: 0.6771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A508S	TCGA-B5-A3FC	UCEC	TCGA	LQPTPQVT	DEG_SCF_FBW7_1	0.2778
p.A508S	DO41871	UCEC	ICGC	LQPTPQVT	DEG_SCF_FBW7_1	0.2778
p.S506L	TCGA-DF-A2KU	UCEC	TCGA	LQPTPQVT	DEG_SCF_FBW7_1	0.2222
p.S506L	DO223286	UCEC	ICGC	LQPTPQVT	DEG_SCF_FBW7_1	0.2222
p.G521E	DO222647	MELA	ICGC	LQPTPQVT	DEG_SCF_FBW7_1	0.2222
p.V509L	SIDM01039	Other Solid Cancers	GDSC	LQPTPQVT	DEG_SCF_FBW7_1	0.3056
p.V509A	SIDM00213	Thyroid Gland Carcinoma	GDSC	LQPTPQVT	DEG_SCF_FBW7_1	0.3056
p.V509A	ACH-000903	Thyroid Cancer	CCLE	LQPTPQVT	DEG_SCF_FBW7_1	0.3056
p.V509A	FTC-133	thyroid	COSMIC	LQPTPQVT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H307	Pinin	DEG_SCF_FBW7_1	510:517	LQPTPQVT	FBXW7	0.7575	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons