DegronMD

Uniprot ID: Q9H307

Source protein: Pinin

Source gene: PNN

Class: DEG_APCC_KENBOX_2

Location: 445:449

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5717

ASA_SCORE: 105.82

COIL: 0.8844

CONS_SCORE: 0.1953

DSS_SCORE: 0.6736

HELIX: 0.0904

FCONS_SCORE: 0.9139

RIG_SCORE: 0.6247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D436H	TCGA-50-5066	LUAD	TCGA	GKENV	DEG_APCC_KENBOX_2	0.0833
p.D436H	DO25040	LUAD	ICGC	GKENV	DEG_APCC_KENBOX_2	0.0833
p.S443F	TCGA-EO-A22U	UCEC	TCGA	GKENV	DEG_APCC_KENBOX_2	0.7222
p.S443F	DO43755	UCEC	ICGC	GKENV	DEG_APCC_KENBOX_2	0.7222
p.T441S	DO229010	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6667
p.T441S	DO229013	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6667
p.T441S	DO229016	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6667
p.T441S	DO229003	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6667
p.T441S	DO229005	COCA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6667
p.K437E	DO231758	LINC	ICGC	GKENV	DEG_APCC_KENBOX_2	0.2222
p.T441I	DO220876	MELA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6667
p.N448K	DO222749	MELA	ICGC	GKENV	DEG_APCC_KENBOX_2	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17027	Zinc finger protein 23	DEG_APCC_KENBOX_2	62:66	GKENV	APC,CDC20,FZR1	0.9286	More...
Q7Z7M9	Polypeptide N-acetylgalactosaminyltransferase 5	DEG_APCC_KENBOX_2	87:91	GKENV	APC,CDC20,FZR1	0.9247	More...
Q9H307	Pinin	DEG_APCC_KENBOX_2	445:449	GKENV	APC,CDC20,FZR1	0.5717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons