DegronMD

Uniprot ID: Q13112

Source protein: Chromatin assembly factor 1 subunit B

Source gene: CHAF1B

Class: DEG_SCF_FBW7_1

Location: 500:507

E3 ligase: FBXW7

DEGRON score: 0.9629

ASA_SCORE: 91.5375

COIL: 0.8711

CONS_SCORE: 0.3236

DSS_SCORE: 0.6744

HELIX: 0.0148

FCONS_SCORE: 1.1898

RIG_SCORE: 0.7133

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P515Q	TCGA-CF-A8HX	BLCA	TCGA	INLTPLKT	DEG_SCF_FBW7_1	0.1111
p.P515Q	DO218996	BLCA	ICGC	INLTPLKT	DEG_SCF_FBW7_1	0.1111
p.P511L	TCGA-P6-A5OG	ACC	TCGA	INLTPLKT	DEG_SCF_FBW7_1	0.2222
p.L502S	TCGA-Z2-AA3V	SKCM	TCGA	INLTPLKT	DEG_SCF_FBW7_1	0.6556
p.L502S	DO51303	SKCM	ICGC	INLTPLKT	DEG_SCF_FBW7_1	0.6556
p.T507M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00087	Plasma Cell Myeloma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00285	Neuroblastoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00844	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00807	Bladder Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00379	Glioma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01133	Other Solid Cancers	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01042	Breast Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.K506Q	SIDM00656	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00846	Cervical Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM01112	Osteosarcoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00954	Breast Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00641	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM01752	Pancreatic Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: INLTPLKT

Degron related mutations and impact score

Drug responses associated with CHAF1B mutations

All proteins holding degron of INLTPLKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13112	Chromatin assembly factor 1 subunit B	DEG_SCF_FBW7_1	500:507	INLTPLKT	FBXW7	0.9629	More...