DegronMD

Uniprot ID: Q13112

Source protein: Chromatin assembly factor 1 subunit B

Source gene: CHAF1B

Class: DEG_SCF_FBW7_1

Location: 500:507

E3 ligase: FBXW7

DEGRON score: 0.9629

ASA_SCORE: 91.5375

COIL: 0.8711

CONS_SCORE: 0.3236

DSS_SCORE: 0.6744

HELIX: 0.0148

FCONS_SCORE: 1.1898

RIG_SCORE: 0.7133

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T507M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00087	Plasma Cell Myeloma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00285	Neuroblastoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00844	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00807	Bladder Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM00379	Glioma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01133	Other Solid Cancers	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01042	Breast Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.T507M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.7423
p.L502S	TCGA-Z2-AA3V	SKCM	TCGA	INLTPLKT	DEG_SCF_FBW7_1	0.6556
p.L502S	DO51303	SKCM	ICGC	INLTPLKT	DEG_SCF_FBW7_1	0.6556
p.K506Q	SIDM00656	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00846	Cervical Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM01112	Osteosarcoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00954	Breast Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM00641	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.K506Q	SIDM01752	Pancreatic Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	0.5833
p.P511L	TCGA-P6-A5OG	ACC	TCGA	INLTPLKT	DEG_SCF_FBW7_1	0.2222
p.P515Q	TCGA-CF-A8HX	BLCA	TCGA	INLTPLKT	DEG_SCF_FBW7_1	0.1111

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Drug responses associated with CHAF1B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of INLTPLKT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13112	Chromatin assembly factor 1 subunit B	DEG_SCF_FBW7_1	500:507	INLTPLKT	FBXW7	0.9629	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: INLTPLKT

Degron related mutations and impact score

Drug responses associated with CHAF1B mutations

All proteins holding degron of INLTPLKT