DegronMD - Q13112(CHAF1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S523Y	TCGA-B5-A1MX	UCEC	TCGA	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation altering degron motif	0.6009
p.S523Y	DO41999	UCEC	ICGC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation altering degron motif	0.6009
p.V484I	TCGA-B5-A3FC	UCEC	TCGA	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.5965
p.V484I	DO41871	UCEC	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.5965
p.R126W	TCGA-BR-4256	STAD	TCGA	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.1389
p.R126W	TCGA-EO-A3AU	UCEC	TCGA	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.1389
p.R126W	DO38743	STAD	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.1389
p.R126W	DO43827	UCEC	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.1389
p.P515Q	TCGA-CF-A8HX	BLCA	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.0833
p.P515Q	TCGA-CF-A8HX	BLCA	TCGA	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation rewiring degron network	0.1111
p.P515Q	TCGA-CF-A8HX	BLCA	TCGA	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation rewiring degron network	0.25
p.P515Q	DO218996	BLCA	ICGC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.0833
p.P515Q	DO218996	BLCA	ICGC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation rewiring degron network	0.1111
p.P515Q	DO218996	BLCA	ICGC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation rewiring degron network	0.25
p.T531M	TCGA-CG-5723	STAD	TCGA	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	DO228338	MALY	ICGC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	DO38376	STAD	ICGC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	SIDM00969	Ovarian Carcinoma	GDSC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	SIDM00948	Burkitt's Lymphoma	GDSC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	SIDM00839	Colorectal Carcinoma	GDSC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	DG-75	haematopoietic and lymphoid tissue	COSMIC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	LoVo	large intestine	COSMIC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T531M	DOV13	ovary	COSMIC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation blocking phosphorylation signal	0.6111
p.T488R	TCGA-CZ-4859	KIRC	TCGA	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6765
p.T488R	DO18602	KIRC	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6765
p.P480Q	TCGA-DU-7298	LGG	TCGA	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.2778
p.P480Q	DO22679	LGG	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation rewiring degron network	0.2778
p.R499K	TCGA-E6-A1LX	UCEC	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7237
p.R499K	DO41020	UCEC	ICGC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7237
p.A105T	TCGA-IB-7651	PAAD	TCGA	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.0556
p.A105T	DO224737	BRCA	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.0556
p.A105T	DO46657	PAAD	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.0556
p.A105T	DO51537	PACA	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.0556
p.A105T	DO228138	PBCA	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.0556
p.P511L	TCGA-P6-A5OG	ACC	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation rewiring degron network	0.1944
p.P511L	TCGA-P6-A5OG	ACC	TCGA	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation rewiring degron network	0.2222
p.P511L	TCGA-P6-A5OG	ACC	TCGA	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation rewiring degron network	0.1389
p.L502S	TCGA-Z2-AA3V	SKCM	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7667
p.L502S	TCGA-Z2-AA3V	SKCM	TCGA	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.6556
p.L502S	DO51303	SKCM	ICGC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.7667
p.L502S	DO51303	SKCM	ICGC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.6556
p.L486V	DO233201	GACA	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6765
p.L486V	SIDM00112	Kidney Carcinoma	GDSC	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6765
p.L486V	ACH-000428	Kidney Cancer	CCLE	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6765
p.L486V	U031	kidney	COSMIC	RRVTLNTLQ	DEG_APCC_DBOX_1	482:490	Mutation altering degron motif	0.6765
p.A112S	DO229022	LICA	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.25
p.D108Y	DO229031	LICA	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.1389
p.Q107H	DO229006	LICA	ICGC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation rewiring degron network	0.1111
p.T521N	DO48677	LIRI	ICGC	VISTPSTE	DEG_SCF_FBW7_2	518:525	Mutation altering degron motif	0.7055
p.W119L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation altering degron motif	0.5904
p.W119L	ACH-000995	Leukemia	CCLE	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation altering degron motif	0.5904
p.W119L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NKENW	DEG_APCC_KENBOX_2	115:119	Mutation altering degron motif	0.5904
p.T507M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00087	Plasma Cell Myeloma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00285	Neuroblastoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00844	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00807	Bladder Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM00379	Glioma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM01133	Other Solid Cancers	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM01042	Breast Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.T507M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.7423
p.K506Q	SIDM00656	Burkitt's Lymphoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM00656	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833
p.K506Q	SIDM00846	Cervical Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM00846	Cervical Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833
p.K506Q	SIDM01112	Osteosarcoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM01112	Osteosarcoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833
p.K506Q	SIDM00954	Breast Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM00954	Breast Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833
p.K506Q	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833
p.K506Q	SIDM00641	Burkitt's Lymphoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM00641	Burkitt's Lymphoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833
p.K506Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833
p.K506Q	SIDM01752	Pancreatic Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	498:506	Mutation altering degron motif	0.5833
p.K506Q	SIDM01752	Pancreatic Carcinoma	GDSC	INLTPLKT	DEG_SCF_FBW7_1	500:507	Mutation altering degron motif	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHAF1B

UniProt ID: Q13112

Entrez ID: 8208

Protein name: Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHAF1B in