DegronMD

Uniprot ID: Q13112

Source protein: Chromatin assembly factor 1 subunit B

Source gene: CHAF1B

Class: DEG_APCC_KENBOX_2

Location: 115:119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5646

ASA_SCORE: 77.16

COIL: 0.5838

CONS_SCORE: 0.525

DSS_SCORE: 0.3075

HELIX: 0.2136

FCONS_SCORE: 1.4286

RIG_SCORE: 0.8202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R126W	TCGA-BR-4256	STAD	TCGA	NKENW	DEG_APCC_KENBOX_2	0.1389
p.R126W	TCGA-EO-A3AU	UCEC	TCGA	NKENW	DEG_APCC_KENBOX_2	0.1389
p.R126W	DO38743	STAD	ICGC	NKENW	DEG_APCC_KENBOX_2	0.1389
p.R126W	DO43827	UCEC	ICGC	NKENW	DEG_APCC_KENBOX_2	0.1389
p.A105T	TCGA-IB-7651	PAAD	TCGA	NKENW	DEG_APCC_KENBOX_2	0.0556
p.A105T	DO224737	BRCA	ICGC	NKENW	DEG_APCC_KENBOX_2	0.0556
p.A105T	DO46657	PAAD	ICGC	NKENW	DEG_APCC_KENBOX_2	0.0556
p.A105T	DO51537	PACA	ICGC	NKENW	DEG_APCC_KENBOX_2	0.0556
p.A105T	DO228138	PBCA	ICGC	NKENW	DEG_APCC_KENBOX_2	0.0556
p.A112S	DO229022	LICA	ICGC	NKENW	DEG_APCC_KENBOX_2	0.25
p.D108Y	DO229031	LICA	ICGC	NKENW	DEG_APCC_KENBOX_2	0.1389
p.Q107H	DO229006	LICA	ICGC	NKENW	DEG_APCC_KENBOX_2	0.1111
p.W119L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NKENW	DEG_APCC_KENBOX_2	0.5904
p.W119L	ACH-000995	Leukemia	CCLE	NKENW	DEG_APCC_KENBOX_2	0.5904
p.W119L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NKENW	DEG_APCC_KENBOX_2	0.5904

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13112	Chromatin assembly factor 1 subunit B	DEG_APCC_KENBOX_2	115:119	NKENW	APC,CDC20,FZR1	0.5646	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons