DegronMD

Uniprot ID: Q13112

Source protein: Chromatin assembly factor 1 subunit B

Source gene: CHAF1B

Class: DEG_APCC_DBOX_1

Location: 498:506

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9807

ASA_SCORE: 97.3

COIL: 0.8089

CONS_SCORE: 0.3255

DSS_SCORE: 0.6487

HELIX: 0.0182

FCONS_SCORE: 1.2104

RIG_SCORE: 0.7293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P515Q	TCGA-CF-A8HX	BLCA	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	0.0833
p.P515Q	DO218996	BLCA	ICGC	RRINLTPLK	DEG_APCC_DBOX_1	0.0833
p.R499K	TCGA-E6-A1LX	UCEC	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	0.7237
p.R499K	DO41020	UCEC	ICGC	RRINLTPLK	DEG_APCC_DBOX_1	0.7237
p.P511L	TCGA-P6-A5OG	ACC	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	0.1944
p.L502S	TCGA-Z2-AA3V	SKCM	TCGA	RRINLTPLK	DEG_APCC_DBOX_1	0.7667
p.L502S	DO51303	SKCM	ICGC	RRINLTPLK	DEG_APCC_DBOX_1	0.7667
p.K506Q	SIDM00656	Burkitt's Lymphoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833
p.K506Q	SIDM00846	Cervical Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833
p.K506Q	SIDM01112	Osteosarcoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833
p.K506Q	SIDM00954	Breast Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833
p.K506Q	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833
p.K506Q	SIDM00641	Burkitt's Lymphoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833
p.K506Q	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833
p.K506Q	SIDM01752	Pancreatic Carcinoma	GDSC	RRINLTPLK	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13112	Chromatin assembly factor 1 subunit B	DEG_APCC_DBOX_1	498:506	RRINLTPLK	APC,CDC20,FZR1	0.9807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons