DegronMD

Uniprot ID: Q13112

Source protein: Chromatin assembly factor 1 subunit B

Source gene: CHAF1B

Class: DEG_APCC_DBOX_1

Location: 482:490

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6107

ASA_SCORE: 101.5556

COIL: 0.6927

CONS_SCORE: 0.258

DSS_SCORE: 0.6333

HELIX: 0.0956

FCONS_SCORE: 0.9347

RIG_SCORE: 0.736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V484I	TCGA-B5-A3FC	UCEC	TCGA	RRVTLNTLQ	DEG_APCC_DBOX_1	0.5965
p.V484I	DO41871	UCEC	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	0.5965
p.T488R	TCGA-CZ-4859	KIRC	TCGA	RRVTLNTLQ	DEG_APCC_DBOX_1	0.6765
p.T488R	DO18602	KIRC	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	0.6765
p.P480Q	TCGA-DU-7298	LGG	TCGA	RRVTLNTLQ	DEG_APCC_DBOX_1	0.2778
p.P480Q	DO22679	LGG	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	0.2778
p.L486V	DO233201	GACA	ICGC	RRVTLNTLQ	DEG_APCC_DBOX_1	0.6765
p.L486V	SIDM00112	Kidney Carcinoma	GDSC	RRVTLNTLQ	DEG_APCC_DBOX_1	0.6765
p.L486V	ACH-000428	Kidney Cancer	CCLE	RRVTLNTLQ	DEG_APCC_DBOX_1	0.6765
p.L486V	U031	kidney	COSMIC	RRVTLNTLQ	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13112	Chromatin assembly factor 1 subunit B	DEG_APCC_DBOX_1	482:490	RRVTLNTLQ	APC,CDC20,FZR1	0.6107	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons