DegronMD

Uniprot ID: Q13112

Source protein: Chromatin assembly factor 1 subunit B

Source gene: CHAF1B

Class: DEG_SCF_FBW7_2

Location: 518:525

E3 ligase: FBXW7

DEGRON score: 0.9584

ASA_SCORE: 92.0625

COIL: 0.8828

CONS_SCORE: 0.2708

DSS_SCORE: 0.7472

HELIX: 0.0923

FCONS_SCORE: 1.0767

RIG_SCORE: 0.6227

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S523Y	TCGA-B5-A1MX	UCEC	TCGA	VISTPSTE	DEG_SCF_FBW7_2	0.6009
p.S523Y	DO41999	UCEC	ICGC	VISTPSTE	DEG_SCF_FBW7_2	0.6009
p.P515Q	TCGA-CF-A8HX	BLCA	TCGA	VISTPSTE	DEG_SCF_FBW7_2	0.25
p.P515Q	DO218996	BLCA	ICGC	VISTPSTE	DEG_SCF_FBW7_2	0.25
p.T531M	TCGA-CG-5723	STAD	TCGA	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	DO228338	MALY	ICGC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	DO38376	STAD	ICGC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	SIDM00969	Ovarian Carcinoma	GDSC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	SIDM00948	Burkitt's Lymphoma	GDSC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	SIDM00839	Colorectal Carcinoma	GDSC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	LoVo	large_intestine	COSMIC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.T531M	DOV13	ovary	COSMIC	VISTPSTE	DEG_SCF_FBW7_2	0.6111
p.P511L	TCGA-P6-A5OG	ACC	TCGA	VISTPSTE	DEG_SCF_FBW7_2	0.1389
p.T521N	DO48677	LIRI	ICGC	VISTPSTE	DEG_SCF_FBW7_2	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13112	Chromatin assembly factor 1 subunit B	DEG_SCF_FBW7_2	518:525	VISTPSTE	FBXW7	0.9584	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons