DegronMD

Uniprot ID: Q8IWY9

Source protein: Codanin-1

Source gene: CDAN1

Class: DEG_SCF_FBW7_2

Location: 197:204

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 87.5375

COIL: 0.9058

CONS_SCORE: 0.5993

DSS_SCORE: 0.6939

HELIX: 0.0479

FCONS_SCORE: 1.4269

RIG_SCORE: 0.6529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T191M	TCGA-32-2616	GBM	TCGA	INPTPVSE	DEG_SCF_FBW7_2	0.1667
p.T191M	DO233179	GACA	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.1667
p.T191M	DO13462	GBM	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.1667
p.R195H	TCGA-AG-A002	READ	TCGA	INPTPVSE	DEG_SCF_FBW7_2	0.2778
p.P201T	TCGA-AJ-A23O	UCEC	TCGA	INPTPVSE	DEG_SCF_FBW7_2	0.7031
p.P201T	DO43290	UCEC	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.7031
p.E205K	TCGA-B5-A0K1	UCEC	TCGA	INPTPVSE	DEG_SCF_FBW7_2	0.3056
p.E205K	DO41839	UCEC	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.3056
p.R196M	TCGA-CG-4306	STAD	TCGA	INPTPVSE	DEG_SCF_FBW7_2	0.3056
p.R196M	DO38567	STAD	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.3056
p.R206Q	TCGA-HU-A4GT	STAD	TCGA	INPTPVSE	DEG_SCF_FBW7_2	0.2778
p.R206Q	DO48020	STAD	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.2778
p.G190W	DO35442	PACA	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.1389
p.K212N	DO232761	PBCA	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.2222
p.K210N	DO232224	PBCA	ICGC	INPTPVSE	DEG_SCF_FBW7_2	0.2778
p.L208I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	INPTPVSE	DEG_SCF_FBW7_2	0.2222
p.L208I	ACH-002256	Leukemia	CCLE	INPTPVSE	DEG_SCF_FBW7_2	0.2222
p.L208I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	INPTPVSE	DEG_SCF_FBW7_2	0.2222
p.S194P	SIDM00660	Colorectal Carcinoma	GDSC	INPTPVSE	DEG_SCF_FBW7_2	0.25
p.S194P	ACH-000985	Colon/Colorectal Cancer	CCLE	INPTPVSE	DEG_SCF_FBW7_2	0.25
p.S194P	LS-411N	large_intestine	COSMIC	INPTPVSE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWY9	Codanin-1	DEG_SCF_FBW7_2	197:204	INPTPVSE	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons