DegronMD

Uniprot ID: Q99459

Source protein: Cell division cycle 5-like protein

Source gene: CDC5L

Class: DEG_SCF_FBW7_1

Location: 435:442

E3 ligase: FBXW7

DEGRON score: 0.8775

ASA_SCORE: 82.2625

COIL: 0.8951

CONS_SCORE: 0.3089

DSS_SCORE: 0.7082

HELIX: 0.0184

FCONS_SCORE: 0.69

RIG_SCORE: 0.6501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P425L	DO222439	BTCA	ICGC	INSTPGRT	DEG_SCF_FBW7_1	0.0556
p.P443S	DO229259	THCA	ICGC	INSTPGRT	DEG_SCF_FBW7_1	0.3056
p.R426Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	INSTPGRT	DEG_SCF_FBW7_1	0.0833
p.R426Q	ACH-002256	Leukemia	CCLE	INSTPGRT	DEG_SCF_FBW7_1	0.0833
p.R426Q	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	INSTPGRT	DEG_SCF_FBW7_1	0.0833
p.R445P	SIDM00704	Small Cell Lung Carcinoma	GDSC	INSTPGRT	DEG_SCF_FBW7_1	0.25
p.R445P	ACH-000639	Lung Cancer	CCLE	INSTPGRT	DEG_SCF_FBW7_1	0.25
p.R445P	NCI-H211	lung	COSMIC	INSTPGRT	DEG_SCF_FBW7_1	0.25
p.N449Y	SIDM00704	Small Cell Lung Carcinoma	GDSC	INSTPGRT	DEG_SCF_FBW7_1	0.1389
p.N449Y	ACH-000639	Lung Cancer	CCLE	INSTPGRT	DEG_SCF_FBW7_1	0.1389
p.N449Y	NCI-H211	lung	COSMIC	INSTPGRT	DEG_SCF_FBW7_1	0.1389
p.P439L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	INSTPGRT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99459	Cell division cycle 5-like protein	DEG_SCF_FBW7_1	435:442	INSTPGRT	FBXW7	0.8775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons