DegronMD - Q99459(CDC5L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S417C	TCGA-78-7155	LUAD	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation blocking phosphorylation signal	0.7222
p.S417C	DO23590	LUAD	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation blocking phosphorylation signal	0.7222
p.R477C	TCGA-AJ-A3BH	UCEC	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.8301
p.R477C	DO228241	LICA	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.8301
p.R477C	DO41638	UCEC	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.8301
p.L423P	TCGA-AP-A051	UCEC	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation rewiring degron network	0.1111
p.L423P	DO42673	UCEC	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation rewiring degron network	0.1111
p.R473Q	TCGA-BR-6801	STAD	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.25
p.R473Q	DO38253	STAD	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation rewiring degron network	0.25
p.G382V	TCGA-D6-A6EO	HNSC	TCGA	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.3056
p.G382V	DO52083	HNSC	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.3056
p.E389D	TCGA-DB-A4XH	LGG	TCGA	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation altering degron motif	0.6758
p.E389D	DO44557	LGG	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation altering degron motif	0.6758
p.K487N	TCGA-F5-6814	READ	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation blocking ubiquitination signal	0.6944
p.K487N	DO36556	READ	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation blocking ubiquitination signal	0.6944
p.F392Y	TCGA-FW-A3R5	SKCM	TCGA	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.25
p.F392Y	DO37406	SKCM	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.25
p.P397A	TCGA-S5-A6DX	BLCA	TCGA	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.1111
p.P397A	DO51903	BLCA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.1111
p.F413L	TCGA-S5-A6DX	BLCA	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation altering degron motif	0.587
p.F413L	DO51903	BLCA	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation altering degron motif	0.587
p.K487R	TCGA-Y8-A897	KIRP	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation blocking ubiquitination signal	0.6944
p.K487R	DO51571	KIRP	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation blocking ubiquitination signal	0.6944
p.R399Q	TCGA-YL-A8SF	PRAD	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation rewiring degron network	0.0833
p.R399Q	TCGA-YL-A8SF	PRAD	TCGA	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.0556
p.R399Q	DO51428	PRAD	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation rewiring degron network	0.0833
p.R399Q	DO51428	PRAD	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.0556
p.P425L	DO222439	BTCA	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	408:415	Mutation rewiring degron network	0.0556
p.P425L	DO222439	BTCA	ICGC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.0556
p.P397S	DO233908	GACA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.1111
p.G381V	DO229008	LICA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation rewiring degron network	0.2778
p.P386S	DO222749	MELA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	383:389	Mutation altering degron motif	0.6752
p.P443S	DO229259	THCA	ICGC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.3056
p.R426Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.0833
p.R426Q	ACH-002256	Leukemia	CCLE	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.0833
p.R426Q	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.0833
p.G479W	SIDM00733	Small Cell Lung Carcinoma	GDSC	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.6714
p.G479W	ACH-000525	Lung Cancer	CCLE	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.6714
p.G479W	NCI-H2171	lung	COSMIC	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.6714
p.R445P	SIDM00704	Small Cell Lung Carcinoma	GDSC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.25
p.R445P	ACH-000639	Lung Cancer	CCLE	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.25
p.R445P	NCI-H211	lung	COSMIC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.25
p.N449Y	SIDM00704	Small Cell Lung Carcinoma	GDSC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.1389
p.N449Y	ACH-000639	Lung Cancer	CCLE	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.1389
p.N449Y	NCI-H211	lung	COSMIC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation rewiring degron network	0.1389
p.P439L	SIDM00429	B-Lymphoblastic Leukemia	GDSC	INSTPGRT	DEG_SCF_FBW7_1	435:442	Mutation altering degron motif	0.7582
p.R477H	ACH-001562	Lung Cancer	CCLE	LRLGLLGLP	DEG_APCC_DBOX_1	476:484	Mutation altering degron motif	0.8244

Kaplan plot for CDC5L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC5L

UniProt ID: Q99459

Entrez ID: 988

Protein name: Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC5L in