DegronMD

Uniprot ID: Q99459

Source protein: Cell division cycle 5-like protein

Source gene: CDC5L

Class: DEG_SCF_FBW7_2

Location: 383:389

E3 ligase: FBXW7

DEGRON score: 0.8954

ASA_SCORE: 88.9714

COIL: 0.877

CONS_SCORE: 0.4878

DSS_SCORE: 0.5448

HELIX: 0.0506

FCONS_SCORE: 0.9269

RIG_SCORE: 0.6762

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E389D	TCGA-DB-A4XH	LGG	TCGA	LNTPLHE	DEG_SCF_FBW7_2	0.6758
p.E389D	DO44557	LGG	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.6758
p.P386S	DO222749	MELA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.6752
p.G382V	TCGA-D6-A6EO	HNSC	TCGA	LNTPLHE	DEG_SCF_FBW7_2	0.3056
p.G382V	DO52083	HNSC	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.3056
p.G381V	DO229008	LICA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.2778
p.F392Y	TCGA-FW-A3R5	SKCM	TCGA	LNTPLHE	DEG_SCF_FBW7_2	0.25
p.F392Y	DO37406	SKCM	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.25
p.P397A	TCGA-S5-A6DX	BLCA	TCGA	LNTPLHE	DEG_SCF_FBW7_2	0.1111
p.P397A	DO51903	BLCA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.1111
p.P397S	DO233908	GACA	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.1111
p.R399Q	TCGA-YL-A8SF	PRAD	TCGA	LNTPLHE	DEG_SCF_FBW7_2	0.0556
p.R399Q	DO51428	PRAD	ICGC	LNTPLHE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99459	Cell division cycle 5-like protein	DEG_SCF_FBW7_2	383:389	LNTPLHE	FBXW7	0.8954	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons