DegronMD

Uniprot ID: Q99459

Source protein: Cell division cycle 5-like protein

Source gene: CDC5L

Class: DEG_SCF_FBW7_1

Location: 408:415

E3 ligase: FBXW7

DEGRON score: 0.9882

ASA_SCORE: 81.7875

COIL: 0.9001

CONS_SCORE: 0.4368

DSS_SCORE: 0.6606

HELIX: 0.0356

FCONS_SCORE: 0.973

RIG_SCORE: 0.7282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S417C	TCGA-78-7155	LUAD	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	0.7222
p.S417C	DO23590	LUAD	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	0.7222
p.L423P	TCGA-AP-A051	UCEC	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	0.1111
p.L423P	DO42673	UCEC	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	0.1111
p.F413L	TCGA-S5-A6DX	BLCA	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	0.587
p.F413L	DO51903	BLCA	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	0.587
p.R399Q	TCGA-YL-A8SF	PRAD	TCGA	VLSTPFRT	DEG_SCF_FBW7_1	0.0833
p.R399Q	DO51428	PRAD	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	0.0833
p.P425L	DO222439	BTCA	ICGC	VLSTPFRT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99459	Cell division cycle 5-like protein	DEG_SCF_FBW7_1	408:415	VLSTPFRT	FBXW7	0.9882	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons