DegronMD

Uniprot ID: Q99459

Source protein: Cell division cycle 5-like protein

Source gene: CDC5L

Class: DEG_APCC_DBOX_1

Location: 476:484

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9328

ASA_SCORE: 69.6778

COIL: 0.5511

CONS_SCORE: 0.5927

DSS_SCORE: 0.4263

HELIX: 0.4316

FCONS_SCORE: 1.2542

RIG_SCORE: 0.7183

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R477C	TCGA-AJ-A3BH	UCEC	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	0.8301
p.R477C	DO228241	LICA	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	0.8301
p.R477C	DO41638	UCEC	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	0.8301
p.R473Q	TCGA-BR-6801	STAD	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	0.25
p.R473Q	DO38253	STAD	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	0.25
p.K487N	TCGA-F5-6814	READ	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	0.6944
p.K487N	DO36556	READ	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	0.6944
p.K487R	TCGA-Y8-A897	KIRP	TCGA	LRLGLLGLP	DEG_APCC_DBOX_1	0.6944
p.K487R	DO51571	KIRP	ICGC	LRLGLLGLP	DEG_APCC_DBOX_1	0.6944
p.G479W	SIDM00733	Small Cell Lung Carcinoma	GDSC	LRLGLLGLP	DEG_APCC_DBOX_1	0.6714
p.G479W	ACH-000525	Lung Cancer	CCLE	LRLGLLGLP	DEG_APCC_DBOX_1	0.6714
p.G479W	NCI-H2171	lung	COSMIC	LRLGLLGLP	DEG_APCC_DBOX_1	0.6714
p.R477H	ACH-001562	Lung Cancer	CCLE	LRLGLLGLP	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99459	Cell division cycle 5-like protein	DEG_APCC_DBOX_1	476:484	LRLGLLGLP	APC,CDC20,FZR1	0.9328	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons