DegronMD

Uniprot ID: O94854

Source protein: Microtubule-actin cross-linking factor 1, isoforms 6/7

Source gene: MACF1

Class: DEG_SIAH_1

Location: 1185:1193

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9956

ASA_SCORE: 84.6778

COIL: 0.9657

CONS_SCORE: 0.3002

DSS_SCORE: 0.3869

HELIX: 0.0159

FCONS_SCORE: 0.9083

RIG_SCORE: 0.7267

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1184V	TCGA-A8-A09Z	BRCA	TCGA	IPAAAVPPM	DEG_SIAH_1	0.3056
p.A1184V	DO5521	BRCA	ICGC	IPAAAVPPM	DEG_SIAH_1	0.3056
p.A1184V	ACH-000998	Colon/Colorectal Cancer	CCLE	IPAAAVPPM	DEG_SIAH_1	0.3056
p.V1182M	TCGA-BA-6873	HNSC	TCGA	IPAAAVPPM	DEG_SIAH_1	0.25
p.V1182M	DO14242	HNSC	ICGC	IPAAAVPPM	DEG_SIAH_1	0.25
p.P1198T	TCGA-DA-A1I1	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	0.1944
p.P1198T	DO37966	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	0.1944
p.S1197F	TCGA-EB-A553	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	0.2222
p.S1197F	DO47329	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	0.2222
p.E1194D	TCGA-EE-A2GT	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	0.3056
p.E1194D	DO37946	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	0.3056
p.E1194D	ACH-000997	Colon/Colorectal Cancer	CCLE	IPAAAVPPM	DEG_SIAH_1	0.3056
p.P1202H	TCGA-EE-A2MG	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	0.0833
p.P1202H	DO37421	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	0.0833
p.M1193V	DO230968	LUSC	ICGC	IPAAAVPPM	DEG_SIAH_1	0.6097
p.M1193V	DO224621	LUSC	ICGC	IPAAAVPPM	DEG_SIAH_1	0.6097
p.A1189V	ACH-000980	Lung Cancer	CCLE	IPAAAVPPM	DEG_SIAH_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_SIAH_1	1185:1193	IPAAAVPPM	SIAH1,SIAH2,SIAH3	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons