DegronMD - O94854(MACF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L670V	TCGA-05-4420	LUAD	TCGA	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.5654
p.L670V	DO24675	LUAD	ICGC	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.5654
p.T1016I	TCGA-59-2363	OV	TCGA	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation altering degron motif	0.7078
p.T1016I	DO29730	OV	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation altering degron motif	0.7078
p.Q696K	TCGA-95-7944	LUAD	TCGA	SRTAAVPTV	DEG_COP1_1	699:707	Mutation rewiring degron network	0.25
p.Q696K	DO25163	LUAD	ICGC	SRTAAVPTV	DEG_COP1_1	699:707	Mutation rewiring degron network	0.25
p.A1184V	TCGA-A8-A09Z	BRCA	TCGA	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.3056
p.A1184V	DO5521	BRCA	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.3056
p.A1184V	ACH-000998	Colon/Colorectal Cancer	CCLE	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.3056
p.S717I	TCGA-AP-A051	UCEC	TCGA	SRTAAVPTV	DEG_COP1_1	699:707	Mutation blocking phosphorylation signal	0.5
p.S717I	DO42673	UCEC	ICGC	SRTAAVPTV	DEG_COP1_1	699:707	Mutation blocking phosphorylation signal	0.5
p.L670I	TCGA-AP-A0LM	UCEC	TCGA	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.6063
p.L670I	TCGA-AP-A1DV	UCEC	TCGA	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.6063
p.L670I	DO43306	UCEC	ICGC	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.6063
p.L670I	DO43186	UCEC	ICGC	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.6063
p.A681T	TCGA-B5-A3FC	UCEC	TCGA	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation rewiring degron network	0.1667
p.A681T	DO41871	UCEC	ICGC	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation rewiring degron network	0.1667
p.V1182M	TCGA-BA-6873	HNSC	TCGA	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.25
p.V1182M	DO14242	HNSC	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.25
p.T1042N	TCGA-BL-A13J	BLCA	TCGA	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation altering degron motif	0.7055
p.T1042N	DO536	BLCA	ICGC	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation altering degron motif	0.7055
p.T844I	TCGA-BR-6707	STAD	TCGA	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation altering degron motif	0.7078
p.T844I	DO38739	STAD	ICGC	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation altering degron motif	0.7078
p.F1009S	TCGA-CK-6746	COAD	TCGA	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.F1009S	DO7938	COAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.F1009S	DO229501	LAML	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.F1009S	DO229457	PRAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.P1012A	TCGA-CK-6746	COAD	TCGA	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.2778
p.P1012A	DO7938	COAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.2778
p.A1044G	TCGA-CV-6960	HNSC	TCGA	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation altering degron motif	0.6429
p.A1044G	DO14156	HNSC	ICGC	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation altering degron motif	0.6429
p.P1004Q	TCGA-D5-6930	COAD	TCGA	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.0556
p.P1004Q	DO10550	COAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.0556
p.P1198T	TCGA-DA-A1I1	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.1944
p.P1198T	DO37966	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.1944
p.S1022F	TCGA-DD-AADY	LIHC	TCGA	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.2778
p.S1022F	TCGA-DD-AADY	LIHC	TCGA	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.1944
p.S1022F	DO52251	LIHC	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.2778
p.S1022F	DO52251	LIHC	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.1944
p.D712V	TCGA-DG-A2KH	CESC	TCGA	SRTAAVPTV	DEG_COP1_1	699:707	Mutation rewiring degron network	0.1944
p.D712V	DO51593	CESC	ICGC	SRTAAVPTV	DEG_COP1_1	699:707	Mutation rewiring degron network	0.1944
p.E689Q	TCGA-DK-A1AF	BLCA	TCGA	SRTAAVPTV	DEG_COP1_1	699:707	Mutation rewiring degron network	0.0556
p.E689Q	DO633	BLCA	ICGC	SRTAAVPTV	DEG_COP1_1	699:707	Mutation rewiring degron network	0.0556
p.S1197F	TCGA-EB-A553	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.2222
p.S1197F	DO47329	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.2222
p.E1194D	TCGA-EE-A2GT	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.3056
p.E1194D	DO37946	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.3056
p.E1194D	ACH-000997	Colon/Colorectal Cancer	CCLE	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.3056
p.P1202H	TCGA-EE-A2MG	SKCM	TCGA	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.0833
p.P1202H	DO37421	SKCM	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.0833
p.A1021T	TCGA-G2-A2EO	BLCA	TCGA	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.3056
p.A1021T	TCGA-G2-A2EO	BLCA	TCGA	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.1667
p.A1021T	DO456	BLCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.3056
p.A1021T	DO456	BLCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.1667
p.P838L	TCGA-GN-A266	SKCM	TCGA	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation altering degron motif	0.6471
p.P838L	DO37432	SKCM	ICGC	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation altering degron motif	0.6471
p.T829A	TCGA-GN-A268	SKCM	TCGA	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.0833
p.T829A	DO37477	SKCM	ICGC	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.0833
p.V1052L	TCGA-GN-A26C	SKCM	TCGA	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation rewiring degron network	0.1667
p.V1052L	DO37782	SKCM	ICGC	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation rewiring degron network	0.1667
p.E675D	TCGA-ND-A4WC	UCS	TCGA	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.5647
p.P674S	TCGA-WE-A8K4	SKCM	TCGA	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.5641
p.P674S	DO224815	BRCA	ICGC	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.5641
p.P674S	DO51281	SKCM	ICGC	LNIFPE	LIG_APCC_ABBA_1	670:675	Mutation altering degron motif	0.5641
p.S699F	DO224815	BRCA	ICGC	SRTAAVPTV	DEG_COP1_1	699:707	Mutation altering degron motif	0.7982
p.P1010L	DO224815	BRCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.2222
p.D832G	DO222558	COCA	ICGC	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.1667
p.S1020P	DO227427	EOPC	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation altering degron motif	0.6752
p.V1025A	DO229028	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.V1025A	DO229028	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.2778
p.V1025A	DO229031	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.V1025A	DO229031	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.2778
p.V1025A	DO229040	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.V1025A	DO229040	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.2778
p.V1025A	DO229229	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.V1025A	DO229229	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.2778
p.V1025A	DO229240	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation rewiring degron network	0.1944
p.V1025A	DO229240	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.2778
p.M1193V	DO230968	LUSC	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation altering degron motif	0.6097
p.M1193V	DO224621	LUSC	ICGC	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation altering degron motif	0.6097
p.D832Y	DO231209	LUSC	ICGC	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.1667
p.S1046Y	DO232224	PBCA	ICGC	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation altering degron motif	0.712
p.P1030T	DO229257	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation altering degron motif	0.7031
p.P1028H	DO229211	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation altering degron motif	0.6583
p.A1038T	DO229248	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.1944
p.A1038T	DO229248	THCA	ICGC	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation rewiring degron network	0.2778
p.D832V	ACH-000101	Leukemia	CCLE	PVTPATT	DEG_SCF_FBW7_1	838:844	Mutation rewiring degron network	0.1667
p.A1034V	ACH-000159	Kidney Cancer	CCLE	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.3056
p.A1034V	ACH-000159	Kidney Cancer	CCLE	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation rewiring degron network	0.1667
p.R700W	ACH-000961	Endometrial/Uterine Cancer	CCLE	SRTAAVPTV	DEG_COP1_1	699:707	Mutation altering degron motif	0.7523
p.A1054V	ACH-000972	Endometrial/Uterine Cancer	CCLE	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation rewiring degron network	0.1111
p.A1189V	ACH-000980	Lung Cancer	CCLE	IPAAAVPPM	DEG_SIAH_1	1185:1193	Mutation altering degron motif	0.5825
p.E1031K	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation altering degron motif	0.591
p.P1017L	ACH-001364	Lung Cancer	CCLE	VPTPEES	DEG_SCF_FBW7_1	1014:1020	Mutation altering degron motif	0.7582
p.V704L	ACH-002120	Skin Cancer	CCLE	SRTAAVPTV	DEG_COP1_1	699:707	Mutation altering degron motif	0.6765
p.P1036L	ACH-002309	Sarcoma	CCLE	VPTPEES	DEG_SCF_FBW7_1	1027:1033	Mutation rewiring degron network	0.25
p.P1036L	ACH-002309	Sarcoma	CCLE	VPTPAES	DEG_SCF_FBW7_1	1040:1046	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MACF1

UniProt ID: O94854

Entrez ID: 643314

Protein name: Microtubule-actin cross-linking factor 1, isoforms 6/7 (Uncharacterized protein KIAA0754)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MACF1 in