DegronMD

Uniprot ID: O94854

Source protein: Microtubule-actin cross-linking factor 1, isoforms 6/7

Source gene: MACF1

Class: DEG_SCF_FBW7_1

Location: 1040:1046

E3 ligase: FBXW7

DEGRON score: 0.9603

ASA_SCORE: 87.6143

COIL: 0.9426

CONS_SCORE: 0.7035

DSS_SCORE: 0.4147

HELIX: 0.028

FCONS_SCORE: 1.4508

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1042N	TCGA-BL-A13J	BLCA	TCGA	VPTPAES	DEG_SCF_FBW7_1	0.7055
p.T1042N	DO536	BLCA	ICGC	VPTPAES	DEG_SCF_FBW7_1	0.7055
p.A1044G	TCGA-CV-6960	HNSC	TCGA	VPTPAES	DEG_SCF_FBW7_1	0.6429
p.A1044G	DO14156	HNSC	ICGC	VPTPAES	DEG_SCF_FBW7_1	0.6429
p.V1052L	TCGA-GN-A26C	SKCM	TCGA	VPTPAES	DEG_SCF_FBW7_1	0.1667
p.V1052L	DO37782	SKCM	ICGC	VPTPAES	DEG_SCF_FBW7_1	0.1667
p.S1046Y	DO232224	PBCA	ICGC	VPTPAES	DEG_SCF_FBW7_1	0.712
p.A1038T	DO229248	THCA	ICGC	VPTPAES	DEG_SCF_FBW7_1	0.2778
p.A1034V	ACH-000159	Kidney Cancer	CCLE	VPTPAES	DEG_SCF_FBW7_1	0.1667
p.A1054V	ACH-000972	Endometrial/Uterine Cancer	CCLE	VPTPAES	DEG_SCF_FBW7_1	0.1111
p.P1036L	ACH-002309	Sarcoma	CCLE	VPTPAES	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_SCF_FBW7_1	1040:1046	VPTPAES	FBXW7	0.9603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons