DegronMD

Uniprot ID: O94854

Source protein: Microtubule-actin cross-linking factor 1, isoforms 6/7

Source gene: MACF1

Class: LIG_APCC_ABBA_1

Location: 670:675

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 85.4167

COIL: 0.7398

CONS_SCORE: 0.6691

DSS_SCORE: 0.5046

HELIX: 0.1503

FCONS_SCORE: 1.1544

RIG_SCORE: 0.7806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L670V	TCGA-05-4420	LUAD	TCGA	LNIFPE	LIG_APCC_ABBA_1	0.5654
p.L670V	DO24675	LUAD	ICGC	LNIFPE	LIG_APCC_ABBA_1	0.5654
p.L670I	TCGA-AP-A0LM	UCEC	TCGA	LNIFPE	LIG_APCC_ABBA_1	0.6063
p.L670I	TCGA-AP-A1DV	UCEC	TCGA	LNIFPE	LIG_APCC_ABBA_1	0.6063
p.L670I	DO43306	UCEC	ICGC	LNIFPE	LIG_APCC_ABBA_1	0.6063
p.L670I	DO43186	UCEC	ICGC	LNIFPE	LIG_APCC_ABBA_1	0.6063
p.A681T	TCGA-B5-A3FC	UCEC	TCGA	LNIFPE	LIG_APCC_ABBA_1	0.1667
p.A681T	DO41871	UCEC	ICGC	LNIFPE	LIG_APCC_ABBA_1	0.1667
p.E675D	TCGA-ND-A4WC	UCS	TCGA	LNIFPE	LIG_APCC_ABBA_1	0.5647
p.P674S	TCGA-WE-A8K4	SKCM	TCGA	LNIFPE	LIG_APCC_ABBA_1	0.5641
p.P674S	DO224815	BRCA	ICGC	LNIFPE	LIG_APCC_ABBA_1	0.5641
p.P674S	DO51281	SKCM	ICGC	LNIFPE	LIG_APCC_ABBA_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	LIG_APCC_ABBA_1	670:675	LNIFPE	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons