DegronMD

Uniprot ID: O94854

Source protein: Microtubule-actin cross-linking factor 1, isoforms 6/7

Source gene: MACF1

Class: DEG_SCF_FBW7_1

Location: 838:844

E3 ligase: FBXW7

DEGRON score: 0.7039

ASA_SCORE: 88.5286

COIL: 0.951

CONS_SCORE: 0.3688

DSS_SCORE: 0.8175

HELIX: 0.0151

FCONS_SCORE: 0.7134

RIG_SCORE: 0.6503

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T844I	TCGA-BR-6707	STAD	TCGA	PVTPATT	DEG_SCF_FBW7_1	0.7078
p.T844I	DO38739	STAD	ICGC	PVTPATT	DEG_SCF_FBW7_1	0.7078
p.P838L	TCGA-GN-A266	SKCM	TCGA	PVTPATT	DEG_SCF_FBW7_1	0.6471
p.P838L	DO37432	SKCM	ICGC	PVTPATT	DEG_SCF_FBW7_1	0.6471
p.T829A	TCGA-GN-A268	SKCM	TCGA	PVTPATT	DEG_SCF_FBW7_1	0.0833
p.T829A	DO37477	SKCM	ICGC	PVTPATT	DEG_SCF_FBW7_1	0.0833
p.D832G	DO222558	COCA	ICGC	PVTPATT	DEG_SCF_FBW7_1	0.1667
p.D832Y	DO231209	LUSC	ICGC	PVTPATT	DEG_SCF_FBW7_1	0.1667
p.D832V	ACH-000101	Leukemia	CCLE	PVTPATT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_SCF_FBW7_1	838:844	PVTPATT	FBXW7	0.7039	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons