DegronMD

Uniprot ID: O94854

Source protein: Microtubule-actin cross-linking factor 1, isoforms 6/7

Source gene: MACF1

Class: DEG_SCF_FBW7_1

Location: 1027:1033

E3 ligase: FBXW7

DEGRON score: 0.9607

ASA_SCORE: 97.9286

COIL: 0.9557

CONS_SCORE: 0.2687

DSS_SCORE: 0.5662

HELIX: 0.0173

FCONS_SCORE: 0.5954

RIG_SCORE: 0.6511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1022F	TCGA-DD-AADY	LIHC	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.S1022F	DO52251	LIHC	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.A1021T	TCGA-G2-A2EO	BLCA	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.1667
p.A1021T	DO456	BLCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1667
p.V1025A	DO229028	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.V1025A	DO229031	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.V1025A	DO229040	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.V1025A	DO229229	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.V1025A	DO229240	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.P1030T	DO229257	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.7031
p.P1028H	DO229211	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.6583
p.A1038T	DO229248	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.A1034V	ACH-000159	Kidney Cancer	CCLE	VPTPEES	DEG_SCF_FBW7_1	0.3056
p.E1031K	ACH-000984	Endometrial/Uterine Cancer	CCLE	VPTPEES	DEG_SCF_FBW7_1	0.591
p.P1036L	ACH-002309	Sarcoma	CCLE	VPTPEES	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_SCF_FBW7_1	1014:1020	VPTPEES	FBXW7	0.9144	More...
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_SCF_FBW7_1	1027:1033	VPTPEES	FBXW7	0.9607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons