DegronMD

Uniprot ID: O94854

Source protein: Microtubule-actin cross-linking factor 1, isoforms 6/7

Source gene: MACF1

Class: DEG_SCF_FBW7_1

Location: 1014:1020

E3 ligase: FBXW7

DEGRON score: 0.9144

ASA_SCORE: 98.1429

COIL: 0.9479

CONS_SCORE: 0.2448

DSS_SCORE: 0.599

HELIX: 0.0261

FCONS_SCORE: 1.014

RIG_SCORE: 0.6224

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1016I	TCGA-59-2363	OV	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.7078
p.T1016I	DO29730	OV	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.7078
p.F1009S	TCGA-CK-6746	COAD	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.F1009S	DO7938	COAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.F1009S	DO229501	LAML	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.F1009S	DO229457	PRAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.P1012A	TCGA-CK-6746	COAD	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.P1012A	DO7938	COAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.P1004Q	TCGA-D5-6930	COAD	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.0556
p.P1004Q	DO10550	COAD	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.0556
p.S1022F	TCGA-DD-AADY	LIHC	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.S1022F	DO52251	LIHC	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2778
p.A1021T	TCGA-G2-A2EO	BLCA	TCGA	VPTPEES	DEG_SCF_FBW7_1	0.3056
p.A1021T	DO456	BLCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.3056
p.P1010L	DO224815	BRCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.2222
p.S1020P	DO227427	EOPC	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.6752
p.V1025A	DO229028	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.V1025A	DO229031	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.V1025A	DO229040	LICA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.V1025A	DO229229	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.V1025A	DO229240	THCA	ICGC	VPTPEES	DEG_SCF_FBW7_1	0.1944
p.P1017L	ACH-001364	Lung Cancer	CCLE	VPTPEES	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_SCF_FBW7_1	1014:1020	VPTPEES	FBXW7	0.9144	More...
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_SCF_FBW7_1	1027:1033	VPTPEES	FBXW7	0.9607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons